Orthopädie und
Traumatologie

Prof. Dr.med. et Dr.sc.nat. Bruno Fuchs

Chefarzt, Leiter Orthopädische Tumorchirurgie
Klinik für Orthopädie und Traumatologie

Fax 052 266 45 10

Spezialisierung
Abklärung und Behandlung von Knochen- und Weichteiltumoren am Muskuloskelettalen System:

  • Begleitung und Führung von Patienten mit Knochen- und Weichteiltumoren.
  • Koordination und Management von Patienten innerhalb der Disziplinen im Rahmen des Sarkomboards
  • Durchführung von Biopsien jeglicher Art in Zusammenarbeit mit den Radiologen
  • Operative Entfernung sowie Rekonstruktion von gut- und bösartigen Knochentumoren des Muskuloskelettalen Systems (inkl. Osteosarkom, Ewing’s Sarkom, und Chondrosarkom) von Kindern und Erwachsenen
  • Operative Entfernung und wenn nötig Rekonstruktion von gut- und bösartigen Tumoren der Weichteile (Muskelgewebe, Fettgewebe, Gefässe und Nerven etc) des Muskuloskelettalen Systems (inkl. pleomorphe Sarkome; Liposarkome etc), von Kindern und Erwachsenen
Ausbildung
1992Abschluss Medizin Studium, Medizinische Fakultät Zürich
1997USLME I / II (United States Medical Licensing Examination)
2004Abschluss (Tumor-)Molekularbiologie Studium, Mayo Graduate School
Ausbildungsstellen und klinische Tätigkeit
2017 –
heute
Chefarzt, Leiter Orthopädische Tumorchirurgie KSW
2017 –
heute
Gründungsmitglied und Senior Consultant Sarkomboard/Sarkomzentrum USZ
2012 –
2017
Gründungsmitglied, Leiter Sarkomzentrum UZH, und Konsiliarius USZ
2005 – 2016Leiter Orthopädische Forschung, Universitätsklinik Balgrist
2005 – 2016Leitender Arzt Tumorchirurgie, Universitätsklinik Balgrist
2004Oberarzt, Universitätsklinik Balgrist
2000 – 2004Graduate School in Biomedical Sciences, Molecular & Tumor Biology, Mayo College of Medicine, Rochester, MN, USA
1998 – 2000Musculoskeletal Oncology Fellowship, Mayo Clinic, Rochester, MN, USA
1996 – 1998Assistenzarzt Orthopädie & Traumatologie, Universitätsklinik Balgrist, Zürich, sowie Inselspital, Bern
1993 – 1995Assistenzarzt Allgemeine Chirurgie & Neurochirurgie
Diplome / Ernennungen
1993MD Dissertation, Universität Zürich
1999Instructor, Department of Orthopedics, Mayo Clinic, Rochester, MN, USA
2000Assistant Professor, Department of Orthopedics, Mayo Clinic, Rochester, MN, USA
2004PhD Dissertation, Biomedical Sciences, Tumor Biology, Mayo Graduate School, Mayo College of Medicine, Rochester, MN, USA
2005Assistenzprofessor, Medizinische Fakultät, Universität Zürich
2005Facharzt FM für Orthopädische Chirurgie und Traumatologie des Bewegungsapparates
2010Extraordinarius, Medizinische Fakultät, Universität Zürich
2017Professor an der Universität Zürich

Mitgliedschaften

  • SwissOrthopaedics
  • FMH (Foederatio Medici Helveticorum)
  • Mayo Clinic Orthopedic Alumni Association
  • IVINS Society; FH-Sim Society
  • CTOS (Connective Tissue Oncology Society)
  • MSTS (Musculoskeletal Tumor Society)
  • EMSOS (European Musculoskeletal Oncology Society)
  • ISS (International Skeletal Society)
  • Swiss MD-PhD Society

Akademische Stellung
Professor an der Universität Zürich
Akademische Aktivitäten

  • Drittmittel Grants: Insgesamt > 10 Mio sFr; ua von EuroNanoMed; Schweizerischer Nationalfonds SNF; HSM Programm for Muskuloskelettale Onkologie des Kantons Zürich; Zürcher Krebsliga; etc.
  • Reviewer für SNF, Schweizerische, Deutsche und Zürcher Krebsliga, sowie > 40 internationale perr-reviewed Journals seit 2008 (ua Nature, Cancer Research; J Cell Mol Medicine; J Nuclear Medicine; ect)
  • Präsentationen seit 2008: 132 an nationalen Meetings; 51 an internationalen Meetings; und 59 eingeladene Präsentationen.
Preise / Ehrungen
1998Charles S. NEER Award (Clinical Category) of the American Society of Shoulder and Elbow Surgeons ASES; for the study: “The Clinical and Structural Results of Direct Repair of Massive Tears of the Rotator Cuff”.
1999Patrick J.KELLY Basic Research Award (special fellows category) of the Department of Orthopedics, Mayo Clinic and Foundation; for the study: “Development of Genetic Landmarks for Comparative Expression Genomics of Osteogenic Sarcoma”.
2001One-Year-Scholarship from the Swiss Society of Orthopedic Surgeons
2001Jubiläumspreis of the Swiss Radiological Society: Painful Lumbar Disc Derangement: Relevance of Endplate Abnormalities at MR imaging.
2002One-Year-Scholarship from the Swiss Society of Orthopedic Surgeons
2003Young Investigator Career Development Fellowship Award
for Orthopaedic Surgery, offered by the European Federation of National Associations of Orthopaedics and Traumatology and Zimmer
(EFORT-ZIMMER AWARD)
2004EW.Johnson Award of the Mid-America Orthopaedic Association, for the study: “Operative Management of Sacro-coccygeal Chordoma”
20071st Place and Best “First Time Presentation of a Resident”, Swiss Orthopedic Society, Montreux, Switzerland, for the study:
“Rare Diaphyseal Lesions of the Ulna: Surgical Treatment Considerations”;
2008Best Presentation at the 14th Annual Meeting of the Swiss Bone and Mineral Society, Davos, GR, Switzerland, for the study:
“Cyr61 Expression in Human Osteosarcoma Correlates with Tumor Metastasis”
2008The 2008/2009 Limb Preservation Foundation Pilot Research Grant Award, The Limb Preservation Foundation, Denver, Colorado, USA.
“Assessment of Intraarterial Chemotherapy in an Osteosarcoma Mouse Model of Spontaneous Metastasis.”
2011Travelling Fellowship Award (student) of the International Skeletal Society (ISS) for the Special Scientific Session of the 2011 Meeting in San Diego, CA, USA for the study: “Evaluation of the Diagnostic Power of Six PET Tracers in an Orthotopic Intratibial Osteosarcoma Mouse Model
2012Swiss Bone and Mineral Research Society (SBMS) Basic Research Award 2012, for the study on: „Cyr61 indicates Poor Survival in Osteosarcoma Patients and Promotes Intratibial Xenograft Primary Tumor Growth and Lung Metastasis in Mice”
2015Maurice E.Müller Research Prize 2015; presented at the 75th Meeting of the Swiss Society of Orthopedic Surgeons (SwissOrthopaedics), Basel, Switzerland, for the study: Prognostic Value and In-vitro Biological Relevance of Neuropilin 1 and Neuropilin-2 in Osteosarcoma”

(Stand Dezember 13, 2016: H-index 36; citations 5225; Google scholar)

  1. B. Fuchs, D. Weishaupt, M. Zanetti, J. Hodler, C. Gerber.  Fatty degeneration of
    the muscles of the rotator cuff:  Assessment by CT versus MR Imaging.
    J Shoulder Elbow Surg  Vol 6 Nov-Dec, 8:599-605, 1999
  2. B. Fuchs, K. Zhang, MG Rock, ME Bolander, G. Sarkar.  Repeat cDNA synthesis and RT-PCR with the same source of RNA.
    Molecular Biotechnology Vol 12:231-235, 1999
  3. B. Fuchs, K. Zhang, MG Rock, ME Bolander, G. Sarkar.  High temperature
    cDNA synthesis by AMV reverse transcriptase improves the specificity of PCR.
    Molecular Biotechnology Vol 12:237-240, 1999
  4. B. Fuchs, B. Jost, C. Gerber.  Posterior Inferior Capsular Shift for the Treatment of Recurrent, Voluntary Posterior Shoulder Subluxation.
    J Bone Joint Surg-Am. 82A:16-25, 2000
  5. C. Gerber, B. Fuchs, J. Hodler.  The Results of the Repair of Massive Tears of the Rotator Cuff.
    J Bone Joint Surg-Am. 82A: 505-515, 2000
  6. B. Fuchs, K.Zhang, ME Bolander, G. Sarkar.  Identification of differentially expressed genes by mutually subtracted RNA fingerprinting.
    Analytical Biochem Nov 286(1):91-98, 2000
  7. B. Fuchs, K.Zhang, ME Bolander, G. Sarkar.  Differential mRNA fingerprinting by preferential amplification of coding sequences.
    Gene   258:155-163, 2000
  8. B. Fuchs, AM Davis, JS. Wunder, RS Bell, BA Masri, B. Isler, R. Turcotte, MG  Rock.  Sciatic nerve resection in the thigh: A functional evaluation
    Clin Orthop  382: 34-41, 2001
  9. D. Weishaupt, M.Zanetti, Hodler J, K.Min, B. Fuchs, CW Pfirrmann, N. Boos. Painful lumbar disk derangement: Relevance of endplate abnormalities at MR imaging.
    Radiology 218(2):420-427, 2001
  10. B.Fuchs, K.Zhang, A.Schabel, ME Bolander, G.Sarkar: Identification of twenty-two candidate genetic markers for osteogenic sarcoma
    Gene  278:245-252, 2001
  11. B.Fuchs, MJ.Yaszemski, FH.Sim: Resection of the Posterior Pelvis and Lumbar Spine for Sarcoma.
    Clin Orthop  397:12-18, 2002
  12. Todd LT, Yaszemski MJ, Currier BL, Fuchs B, Kim CW, MB.Dekutoski, Sim FH. Bowel and Bladder Function following Major Sacral Resection.
    Clin Orthop 397:36-39, 2002
  13. Talac R, Yaszemski MJ, Currier BL, Fuchs B, Dekutoski MB, Kim CW, Sim FH. Relationship between surgical margins and local recurrence in sarcomas of the spine.
    Clin Orthop 397:127-32, 2002
  14. B.Fuchs, DJ.Pritchard. Etiology of Osteosarcoma.*
    Clin Orthop 397:40-52, 2002 
    *specifically noted as highlight in editorial comment: Clin Orthop 397:2, 2002
  15. B.Fuchs, MI.O’Connor, KR.Kaufman, DJ Padgett, FH.Sim. Iliofemoral arthrodesis and Pseudarthrosis: A functional long-term outcome evaluation.
    Clin Orthop 397:29-35, 2002
  16. K.Zhang, N.Dion, B.Fuchs, T.Damron, S.Gitelis, R.Irwin, M.O’Connor, H.Schwartz, SP.Scully, MG.Rock, ME.Bolander, G.Sarkar. The hSEP1 is a novel candidate tumor suppressor gene in osteogenic sarcoma.
    Gene  298:121-127, 2002
  17. B.Fuchs, U.Knothe, R.Hertel, R.Ganz. Femoral Osteotomy and Iliac Graft Vascularization for Femoral Head Osteonecrosis.
    Clin Orthop 412:84-93, 2003
  18. B.Fuchs, C.Inwards, R.Janknecht. Upregulation of the matrix metalloproteinase- gene by the Ewing’s sarcoma associated EWS-ER81 and EWS-Fli1 oncoproteins, c-Jun and p300.
    FEBS Letters  553:104-108, 2003
  19. B.Fuchs, R.Valenzuela, FH.Sim. Pathologic Fracture as a Complication in the Treatment of Ewing’s Sarcoma.
    Clin Orthop 415: 25-30, 2003
    *specifically highlighted in editorial comment: Clin Orthop 415:2-3, 2003
  20. B.Fuchs, BR.Kotajarvi, K.Kaufman, FH.Sim. Functional Outcome of Patients with Rotationplasty about the knee.
    Clin Orthop 415: 52-58, 2003
    *specifically highlighted in editorial comment: Clin Orthop 415:2-3, 2003
  21. B.Fuchs, R.Valenzuela, CS. Arndt, IA.Petersen, FH.Sim. Ewing’s sarcoma and the Development of Secondary Malignancies.
    Clin Orthop 415: 82-89, 2003
    *specifically highlighted in editorial comment: Clin Orthop 415:2-3, 2003
  22. B.Fuchs, R.Valenzuela, C.Inwards, FH.Sim, MG.Rock: Complications in Long-term Survivors of Ewing’s sarcoma.
    Cancer  98(12):2687-92, 2003
  23. B.Fuchs, C.Inwards, R.Janknecht: VEGF expression is Upregulated by EWS-ETS Oncoproteins and Sp1 and may Represent an Independent Predictor of Survival in Ewing’s sarcoma.
    Clin Cancer Res 10:1344-1353, 2004
  24. EY.Chao, B.Fuchs, CM.Rowland, DM.Illstrup, DJ.Pritchard, FH.Sim. Long-term Results of Segmental Prosthesis Fixation by Extra-Cortical Bone Bridging and Ingrowth.
    J Bone Joint Surg Am 86:948-955, 2004
  25. B.Fuchs, FH.Sim. Rotationplasty about the Knee: Surgical Technique and Anatomical Considerations.
    Clin Anat 17(4):345-353, 2004
  26. B.Fuchs, C.Inwards, SP.Scully, R.Janknecht. hTERT is Highly Expressed in Ewing’s Sarcoma and Activated by EWS-ETS Oncopoteins.
    Clin Orthop 426:64-68, 2004
  27. I.Dickey, P.Rose, B.Fuchs, D., Okuno, S, Wold L, FH.Sim, SP.Scully. Dedifferentiated Chondrosarcoma: Updated Ouctomes with Current Treatment Approaches.
    J Bone Joint Surg 86-Am 11:2412-2418, 2004
  28. FH.Sim, B.Fuchs, DJ.Jacofsky. Innovations in Musculoskeletal Oncologic Surgery over the Year 2000.
    Chir Organi Mov 89(3):181-190, 2004
  29. B. Fuchs, RT.Trousdale, MG. Rock.  Solitary Bony Metastasis from Renal Cell Carcinoma: Significance of Surgical Treatment.
    Clin Orthop 431:187-192, 2005
  30. B.Fuchs, SP.Steinmann, AT.Bishop: Free Vascularized Corticoperiosteal Bone Graft for the Treatment of Persistent Nonunion of the Clavicle.
    J Shoulder Elbow Surg 14(3):264-268, 2005
  31. B.Fuchs, MI.O’Connor, DJ.Padget, KR.Kaufman, FH.Sim: Arthrodesis of the Shoulder after Tumor Resection
    Clin Orthop 436:202-207, 2005
  32. B.Fuchs, ID.Dickey, MJ.Yaszemski, C.Inwards, FH.Sim. Operative Management of Sacral Chordoma
    J Bone Joint Surg 87-Am 10:2211-2216, 2005
  33. ID.Dickey, RR.Hugate, B.Fuchs, MJ.Yaszemski, FH.Sim: Reconstruction after Total Sacrectomy: Early Experience with a New Surgical Technique
    Clin Orthop 438:42-50, 2005
  34. B.Fuchs, RJ.Spinner, MG.Rock: MPNST Malignant Peripheral Nerve Sheath Tumors: An update
    J Surg Orthop Adv 14:168-174, 2005
  35. B.Fuchs, MK.Gilbart, J.Hodler, C.Gerber: The Clinical and Structural Results of Open Repair of an Isolated One-tendon Tear of the Rotator Cuff.
    J Bone Joint Surg 88-Am 2:309-316, 2006
  36. SF.Fucentese, A.von Roll, PP.Koch, DR.Epari, B.Fuchs, PB.Schoettle: The Patella Morphology in Trochlear Dysplasia – A Comparative MRI Study.
    Knee 13:145-150, 2006
  37. A. Srivastava*, B.Fuchs*, K.Zhang, M.Ruan, C.Halder, E.Mahlum, K.Weber, ME.Bolander, G.Sarkar: High WT1 Expression is Associated with poor survival of patients with Osteogenic sarcoma metastasis.
    Clin Cancer Res 12(14): 4237-4243, 2006*Co-First-Authorship
  38. C.Ossendorf, B.Fuchs, P.Koch: Femoral Stress Fracture after Computer Navigated Total Knee Arthroplasty.
    Knee 13(5):397-399, 2006
  39. F.Mueller, B.Fuchs, B.Kaser: Comparative Biology of Human and Canine Osteosarcoma
    Anticancer Res 27(1A):155-164, 2007
  40. D.Walters, R.Muff, B.Langsam, P.Gruber, W.Born, Fuchs B: Taurolidine: A novel Anti-neoplastic Agent induces Apoptosis of Osteosarcoma Cell Lines.
    Invest New Drugs 25(4):305-12, 2007
  41. B.Fuchs, E.Mahlum, C.Halder, A.Maran, M.Yaszemski, B.Bode, M.Bolander, G.Sarkar: High Expression of Tumor Endothelial Marker 7 is associated with Metastasis and poor Survival of Patients with Osteogenic Sarcoma.
    Gene  399(2):137-143,  2007
  42. R.Muff, N.Nigg, P.Gruber, D.Walters, W.Born, B.Fuchs: Altered Morphology, Nuclear Stability and Adhesion of Highly Metastatic Derivatives of Osteoblast-like SaOS-2 Osteosarcoma Cells
    Anticancer Res  27(6B): 3973-3979, 2007
  43. N.Bodmer, DK.Walters, B.Fuchs: Pemetrexed, a Multitargeted Antifolate Drug, Demonstrates Lower Efficacy in Comparison to Methotrexate against Osteosarcoma Cell Lines.
    Pediatr Blood Cancer 50(4):905-8, 2008
  44. K.Husmann, R.Muff, W.Born, ME.Bolander, G.Sarkar, B.Fuchs: Cathepsins and Osteosarcoma: Expression Analysis identifies Cathepsin K as a Prognostic Indicator of Metastasis.
    Mol Carcinog 47:66-73, 2008
  45. HA.Ruediger, B.Fuchs, A.von Campe, C.Gerber: Measurements of Shoulder Mobility by Patient and Surgeon Correlate Poorly: A Prospective Study.
    J Shoulder Elbow Surg 17(2):255-60, 2008
  46. DK.Walters, P.Steinmann, B.Langsam, S.Schmutz, W.Born, B.Fuchs: Identification of Potential Chemoresistance Genes in Osteosarcoma
    Anticancer Res 28:673-80, 2008
  47. DK.Walters, R.Muff, B.Langsam, W.Born, B.Fuchs: Cytotoxic Effects of Curcumin on Osteosarcoma Cell Lines
    Invest New Drugs 26:289-97, 2008
  48. B.Fuchs, C.Ossendorf, T.Leerapun, FH.Sim: Intercalary Segmental Reconstruction for Bone Defects.
    Europ J Surgical Oncol 34(12):1271-6, 2008
  49. B.Fuchs, M.Zumstein, F.Regenfelder, P.Steinmann, T.Fuchs, K.Husmann, J.Hellermann, B.Jost, J.Hodler, W.Born, C.Gerber. Upregulation of alpha-skeletal muscle actin and myosin heavy polypeptide gene products in degenerating rotator cuff muscles.
    J Orthop Res 26:1007-11, 2008
  50. C.Ossendorf, GM.Studer, B.Bode, B.Fuchs: Sclerosing Epithelioid Fibrosarcoma: Case Presentation and a Systematic Review
    Clin Orthop Rel Res 466:1485-1491, 2008
  51. S.Schmutz, T.Fuchs, F.Regenfelder, P.Steinmann, M.Zumstein, B.Fuchs. Expression of Atrophy mRNA relates to Tendon Tear Size in Supraspinatus Muscle.
    Clin Orthop Rel Res  467(2):457-464, 2009
  52. E.Frey, F.Regenfelder, P.Sussmann, M.Zumstein,  C.Gerber, W.Born, B.Fuchs: Adipogenic and Myogenic Gene Expression in Rotator Cuff Muscle of the Sheep after Tendon Tear.
    J Orthop Res 27(4):504-509, 2009
  53. B.Fuchs, N.Hoekzema, D.Larson, C.Inwards, FH.Sim: Osteosarcoma of the Pelvis: Outcome Analysis of Surgical Treatment.
    Clin Orthop Rel Res 467(2):510-518, 2009
  54. J.Yuan, C.Ossendorf, JP.Szatkowski, J.Bronk, A.Maran, M.Yaszemski, ME.Bolander, G.Sarkar, B.Fuchs: Osteoblastic and Osteolytic Human Osteosarcomas can be studied with a New Xenograft Mouse Model Producing Spontaneous Metastases
    Cancer Invest  27(4):435-42, 2009
  55. R.Hudek, S.Schmutz, F.Regenfelder, B.Fuchs, PP.Koch. Novel Measurement Technique of the Tibial Slope on Conventional MRI.
    Clin Orthop Rel Res 467:2066-72, 2009
  56. B.Fuchs, W.Born. Molecular and Cellular Mechanisms of Osteosarcoma Metastasis: Current Knowledge and Perspectives (Review)
    Current Orthopaedic Practice 20(6):593-597, 2009
  57. C.Halder, C.Ossendorf, A.Maran, M.Yaszemski, B.Fuchs, G.Sarkar. Preferential Expression of the Secreted and the Membrane Forms of Tumor Endothelial Marker 7 Transcripts in Osteosarcoma.
    Anticancer Res 29(11):4317-22, 2009
  58. C. Ossendorf, GU.Exner, B.Fuchs. A New Incision Technique to Reduce Tibiofemoral Mismatch in Rotationplasty.
    Clin Orthop Rel Res 468:1264-1268, 2010
  59. P.Zwolak, P.Kuehnel, B.Fuchs. Extra-articular Knee Resection for Sarcomas with Preservation of the Extensor Mechanism: Surgical Considerations and Review of Cases
    Clin Orthop Rel Res 469:251-256, 2011
  60. A.Krieg, F.Hefti, B.Speth, L.Guillou, G.Jundt, U.Exner, A.v.Hochstetter, M.Cserhati, B.Fuchs, E.Moushine, A.Kaelin, F.Klenke, K.Siebenrock. Synovial Sarcomas usually Metastasize after  > five Years: A Multicenter, Retrospective Analysis with Minimum Followup of 10 Years for Survivors
    Annals of Oncology 22(2):458-67, 2011
  61. PP.Koch, B.Fuchs, DC. Meyer, SF.Fucentese. Closing Wedge Patellar Osteotomy in Combination with Trochleoplasty.
    Acta Orthop Belg 77(1):116-121, 2011
  62. MJE. Arlt, IJ. Banke, DK. Walters, G. Puskas, P. Steinmann, R. Muff, W. Born, B. Fuchs. LacZ Transgene Expression in the Subcutaneous Dunn / LM8 Osteosarcoma Mouse Model Allows for the Identification of Micrometastasis
    J Orthop Res 29(6):938-46, 2011
  63. R.Hudek, B.Fuchs, F.Regenfelder, PP.Koch. Is Non-contact ACL Injury Associated with the Posterior Tibial and Meniscal Slope?
    Clin Orthop Rel Res 469:2377-84, 2011
  64. B.Fuchs: Current Trends in Musculoskeletal Oncology
    Leading Opinions Orthopädie & Rheumatologie  3:22-24, 2011
  65. P.Steinmann, DK.Walters, MA.Arlt, I.Banke, U.Ziegler, B.Langsam, J.Arbiser, R.Muff, W.Born, B.Fuchs: Antimetastatic Activity of Honokiol in Osteosarcoma.
    Cancer 118(8):2117-27, 2012
  66. A.Sabile, M.Arlt, R.Muff, B.Bode, B.Langsam, J.Bertz, T.Jentzsch, G.Puskas, W.Born, B.Fuchs: Cyr61 indicates Poor Survival in Osteosarcoma Patients and Promotes Intratibial Xenograft Primary Tumor Growth and Lung Metastasis in Mice.
    J Bone Mineral Res 27(1):58-67, 2012
  67. MJE. Arlt, DK. Walters, IP.Banke, P. Steinmann, GJ. Puskas, J.Bertz, K.Rentsch, F.Ehrensperger, W. Born, B. Fuchs. The Antineoplastic Antibiotic Taurolidine Promotes Lung and Liver Metastases in Two Syngeneic Osteosarcoma Mouse Models and Exhibits Severe Liver Toxicity.
    Int J Cancer 131(5):E804-12, 2012 doi: 10.1002/ijc.27378
  68. M.Betz, C.Dumont, B.Fuchs, GU.Exner. Epiphyseal Distraction for Joint Preservation in Malignant Metaphyseal Bone Tumors in Children.
    Clin Orthop Rel Res 470(6):1749-54, 2012
  69. K.Reidy, C.Campanile, R.Muff, W.Born, B.Fuchs. mTHPC-mediated Photodynamic Therapy is Effective in the Metastatic Human 143B Osteosarcoma Cells.
    Photochemistry and Photobiology 88(3):721-7, 2012
  70. M.Erschbamer, B.Bode, FM.Buck, B.Fuchs. A Rare Periosteal Diaphyseal Lesions of the Ulna.
    Open Orthop J 6:8-10, 2012
  71. K.Modaressi, F.Niggli, B.Fuchs. Strategisches Vorgehen bei Verdacht auf Knochensarkom.
    Schweizerische Zeitschrift für Onkologie SZO 2: 12-17, 2012
  72. K.Berndt, J.Vogel, C.Bühler, P.Vogt, W.Born, B.Fuchs. A New Method for Repetitive Drug Infusion into the Femoral Artery of Mice.
    J Am Assoc Lab Animal Science 51(6):825-31, 2012
  73. G.Studer, B.Bode, B.Fuchs. Extremitäten-Weichteilsarkom des Erwachsenen: Stellenwert der Radiotherapie
    Info @ Onkologie 02:14-17, 2012
  74. MJE.Arlt, W.Born, B.Fuchs. Taurolidine: Mode of Administration in Mouse Tumor Models
    Int J Cancer 131(5):E1053-4, 2012 doi:10.1002/ijc.27569
  75. K.Modaressi, B.Fuchs. Die Chirurgische Behandlung von Sarkomen
    Leading Opinions Hämatologie & Onkologie 2:74-76, 2012
  76. M.Arlt, W.Born, B.Fuchs. Improving Visualization of Lung Metastases by Combining X-Gal Staining of LacZ-tagged Tumor Cells with In-situ Perfusion and Fixation of the Lung Tissue
    J Vis Exp (66):e4162, 2012 DOI 10.3791/4162
  77. R.Muff, R.Kumar, S.Botter, W.Born, B.Fuchs: Genes Regulated in Metastatic Osteosarcoma: Evaluation by Microarray Analysis in Four Human and Two Mouse Cell Line Systems.
    Sarcoma 2012; 2012:937506 DOI 10.1155/2012/937506
  78. M.Glanzmann, B.Fuchs, H.Schwyzer. Chronische Ellbogenschmerzen einer Volleyballerin.
    Arthroskopie 1-4, 2012 DOI 10.1007/s00142-012-0711-2
  79. A.Gvozdenovic, MJE. Arlt, C.Campanile, P.Brennecke, K.Husmann, Y. Li, W.Born, R.Muff, B.Fuchs. CD44 Enhances Tumor Formation and Lung Metastasis in Experimental Osteosarcoma and is an Additional Predictor for Poor Patients’ Outcome.
    J Bone Min Res 28(4):838-47, 2013
  80. K.Husmann, MJE.Arlt, R.Muff, B.Langsam, J.Bertz, W.Born, B.Fuchs. Matrix Metalloproteinase 1 promotes Tumor Formation and Lung Metastasis in an Intratibial Injection Osteosarcoma Mouse Model.
    BBA Molecular Basis of Disease 1832(2):347-54, 2013
  81. T.Jentzsch, M.Erschbamer, F.Seeli, B.Fuchs. Extensor Function After Medial Gastrocnemius Flap Reconstruction of the Proximal Tibia.
    Clin Orthop Rel Res 471(7):2333-9, 2013
  82. C.Campanile, M.Arlt, A.Gvozdenovic, P.Brennecke, A.Sabile, M.Honer, C.Fischer, A.Mueller, S. Ametamey, S.Krämer, R.Schibli, W.Born, B.Fuchs. Characterization of Different Osteosarcoma Phenotypes by PET Imaging in Preclinical Animal Models
    J Nuclear Medicine 54(8):1362-8, 2013
  83. K.Modaressi, B.Fuchs, P.Bode, R.Sutter, M.Decurtins, U.Weber. Osteoblastoma of the Ilium mimicking sacroiliitis.
    Arthritis Rheum 65(6):1674, 2013
  84. A.Gozdenovic, MJE.Arlt, C.Campanile, P.Brennecke, K.Husmann, W.Born, R.Muff, B.Fuchs: Silencing of CD44 Gene Expression in Human 143-B Osteosarcoma Cells Promotes Metastasis of Intratibial Tumors in SCID Mice
    PLosOne 8(4):e60329, 2013
  85. K.Berndt, C.Campanile, R.Muff, E.Strehler, W.Born, B.Fuchs. Evaluation of Quercetin as a Potential Drug in Osteosarcoma Treatment.
    Anticancer Res 33(4):1297-306, 2013
  86. A.Sabile, M.Arlt, R.Muff, B.Bode, B.Langsam, J.Bertz, T.Jentzsch, W.Born, B.Fuchs: Caprin1 promotes Metastasis in an Experimental Animal Model of Osteosarcoma.
    BBA Molecular Basis of Disease 1832(8):1173-82, 2013
  87. S.Crivelli-Ochsner, B.Bode, Y.Nussbaumer-Ochsner, B.Fuchs. Giant Cell Angioblastoma in an Adult: A Unique Presentation.
    Rare Tumors 5e27:98-100, 2013
  88. K.Modaressi, G.Studer, B.Bode, S.Hofer, B.Fuchs. Knochenmetastasen – Abklärung und Therapie. Schlaglicht Schweizerische Aertzte Zeitung, Frühjahr 2013.
    Swiss Med Forum 13(2930):571-79, 2013
  89. K.Wieser, K.Modaressi, F.Seeli, B.Fuchs. Autologous Double-Barrel Vascularized Fibular Bone Graft for Arthrodesis of the Shoulder after Tumor Resection.
    Archives Orthop Traumatol 133(9):1219-24, 2013
  90. P.Brennecke, MA Arlt, R.Muff, C.Campanile, A.Gvozdenovic, K.Husmann, N.Holzwarth, E.Cameroni, F.Ehrensperger, M.Thelen, W.Born, B.Fuchs. Expression of the Chemokine Receptor CXCR7 in CXCR4-Expressing Human 143B Osteosarcoma Cells Enhances Lung Metastases of Intratibial Xenografts in SCID Mice.
    PLosOne  8(9):e74045, 2013
  91. MJE.Arlt, IJ.Banke, J.Bertz, R.Mohan, R.Muff, W.Born, B.Fuchs. Reduced Latency in the Metastatic Niche Contributes to the More Aggressive Phenotype of LM8 Compared to Dunn Osteosarcoma Cells.
    Sarcoma 2013; 2013:404962 doi: 10.1155/2013/404962
  92. D.Meier, C.Campanile, S, Botter, W.Born, B.Fuchs. Cytotoxic Efficacy of Photodynamic Therapy in osteosarcoma Cells in vitro.
    J Vis Exp 2014 Mar 18; (85). Doi:10.3791/51213
  93. P.Brennecke, M.Arlt, K.Husmann, C.Campanile, A.Gvozdenovic, T.D’Apuzzo, M.Thelen, W.Born, B.Fuchs. CXCR4 Antibody Treatment Suppresses Metastatic Spread to the Lung of Intratibial Human Osteosarcoma Xenografts In Mice.
    Clin Exp Metastasis 31(3):339-49, 2014
  94. C.Pauli, B.Fuchs, C.Pfirrmann, JA.Bridge, S.Hofer, B.Bode: Response of an Aggressive Periosteal Aneurysmal Bone Cyst (ABC) of the Radius to Denosumab Therapy.
    World J Surg Oncol 12(1): 17, 2014  Doi: 10.1186/1477-7819-12-17 (IF 1.092)
  95. K.Modaressi, P.Giovanoli, P.Schneider, T.Sulser, C.Werner, B.Bode, B.Fuchs. Rezidivierendes Rektumkarzinom: Sakrektomie mit kompletter dorsaler Exenteration.
    Leading Opinions Orthopedics & Rheumatology 1/14:46-8, 2014
  96. S.Botter, D.Neri, B.Fuchs. Recent Advances in Osteosarcoma.
    Curr Opin Pharmacol 16C:15-23, 2014
  97. NR.Datta, E.Puric, R.Schneider, B.Fuchs, S.Bodis, D.Weber. HYPROSAR: Hyperthermia and Proton Radiotherapy in Soft Tissue Sarcoma.
    Leading Opinions Hämatologie & Onkologie 2:158-60, 2014
  98. M.Arlt, I.Banke, D.Walters, K.Berndt, E.Strehler, W.Born, B.Fuchs. The Use of LacZ-transduced Tumor Cells Enhances the Sensitivity of Micrometastasis Detection: A Comparative Study of Gemcitabine Treatment Efficacy in the Mouse LM8 Osteosarcoma Cell Model.
    J Cancer Res Ther 2(6):89-95, 2014
  99. T.Jentzsch, B.Robl, M.Husmann, B.Bode, B.Fuchs. Worse Prognosis of Osteosarcoma Patients expressing IGF-1 on a Tissue Microarray
    Anticancer Res 34(8):3881-9, 2014
  100. RMR. Kumar, MM.Betz, B.Robl, W.Born, B.Fuchs. ΔNp63alpha Exerts Its Oncogenic Potential via Transcriptionally Regulating GLI2 in Osteosarcoma Cells.
    BMC Cancer 14: 559, 2014
  101. M.Rimann, S.Laternser, A.Gvozdenovic, R.Muff, B.Fuchs, J.Kelm, U.Graf-Hausner. An In-vitro Osteosarcoma 3D Microtissue Model for Drug Development.
    J Biotechnology 189C:129-135, 2014
  102. T.Jentzsch, B.Robl, M.Husmann, B.Bode, B.Fuchs. Expression of MSH2 and MSH6 on a Tissue Microarray in Patients with Osteosarcoma.
    Anticancer Res 34(12):6961-72, 2014
  103. B.Fuchs. Research and Development in Tumour Surgery: The Importance of Team Work.
    Swiss Cancer Research Foundation 1:95-99, 2014
  104. R.Cathomas, C.Rothermundt, B.Bode, B.Fuchs, R.von Moos, M.Schwitter. RANK ligand Blockade with Denosumab in Combination with Sorafenib in Chemorefractory Osteosarcoma: a possible Step forward?
    Oncology 88(4):257-60, 2015
  105. K.Husmann, M.Arlt, P.Jirkof, M.Arras, W.Born, B.Fuchs. Primary Tumour Growth in an Orthotopic Osteosarcoma Mouse Model Is Not Inflenced By Analgesic Treatment with Buprenorphine And Meloxicam.
    Laboratory Animals 49(4):284-93, 2015
  106. B.Robl, C.Pauli, S.Botter, B.Bode, B.Fuchs. Prognostic Value of Tumor Suppressors in Osteosarcoma Before and After Neoadjuvant Chemotherapy.
    BMC Cancer 15(1):379- , 2015
  107. NR.Datta, R.Grobholz, E.Puric, B.Bode, N.Lomax, S.Khan, US. Gaipl, B.Fuchs, S.Bodis. Enhanced Tumour Regression in a Patient of Liposarcoma Treated with Radiotherapy and Hyperthermia: Hint for Dynamic Immunomodulation by Hperthermia.
    Int J Hyperthermia 20:1-4, 2015
  108. A.Boro, M.Arlt, H.Lengnick, B.Robl, M.Husmann, J.Bertz, W.Born, B.Fuchs. Prognostic Value and in-vitro Biological Relevance of Neuropilin 1 and Neuropilin 2 in Osteosarcoma.
    Am J Translational Res 7(3):640-53, 2015
  109. T.Jentzsch, B.Fuchs. Therapie von Sarkomen.
    InFo@Onkologie&Hämatologie 3(5):1-6, 2015
  110. G.Studer, M.Brown, B.Fuchs. Radiotherapie bei Weichteilsarkomen des Erwachsenen: Präoperative und Dosis-Volumen-konformierende Anwendung
    InFo@Onkologie 2:13-15, 2015
  111. S.Hodel, F.Seeli, B.Fuchs. Demographische Analyse von Patienten mit Osteosarkom, Chondrosarkom, Ewing’s Sarkom von einem Sarkomzentrum in der Schweiz.
    PRAXIS Schweizerische Rundschau für Medizin 104(13):673-80, 2015
  112. R.Muff, P.Rath, R.Kumar, K.Husmann, W.Born, M.Baudis, B.Fuchs. Genomic Instability of Osteosarcoma Cell Lines during Long-term in vitro Culture.
    PlosOne 10(5):e0125611, 2015
  113. R.Kumar, B.Fuchs. Hedgehog Signaling Inhibitors as Anti-cancer Agents in Osteosarcoma.
    Cancers  7(2):784-94, 2015
  114. R.Kumar, M.Arlt, B.Robl, A.Kuzmanov, O.Neklyudova, K.Husmann, W.Born, B.Fuchs. Sunitinib Malate (SU-11248) Reduces Intratibial Tumour Burden And Lung Metastasis In a Preclinical Mouse Model Of Osteosarcoma.
    Am J Cancer Res 5(7):2156-68, 2015
  115. K.Husmann, P.Ducommun, A.Sabile, E.Pedersen, W.Born, B.Fuchs. Signal Transduction and Downregulation of C-Met in HGF-stimulated Low and Highly Metastatic Human Osteosarcoma Cell Lines.
    Biochem Biophys Res Commun 464(4):1222-7, 2015
  116. B.Fuchs. Swiss National Sarcoma Advisory Board: Vorstellung des Schweizer Konsensus.
    Leading Opinions Hämatologie&Onkologie 3(15):78-80, 2015
  117. D.Müller, B.Fuchs. Whoops Läsionen bei Weichteilsarkomen.
    InFo@Onkologie&Hämatologie 8:26-29, 2015
  118. M.Ture, J.Barth, F.Angst, A.Aeschlimann, U.Schnyder, N.Zerkiebel, J.Perseus, C.Renner, P.Imesch, B.Fuchs, G.Huber, H.Walt, C.Martin-Soelch, J.Jenewein. Use of Inpatient Rehabilitation for Cancer patients in Switzerland: Who undergoes Cancer Rehabilitation?
    Swiss Medical Weekly December 4, 2015 DOI 10.4414/smw.2015.14214
  119. A.Boro, D.Bauer, W.Born, B.Fuchs. Plasma Levels of MIRNA-155 as a Powerful Diagnostic Marker for Dedifferentiated Liposarcoma.
    Am J Cancer Res 6(2):544-52, 2016
  120. R.Muff, S.Botter, K.Husmann, J.Tchinda, P.Selvam, F.Seeli-Maduz, B.Fuchs. Explant Culture of Sarcoma Patients’ Tissue.
    Lab Invest  DOI:10.1038 April 26, 2016
  121. O.Neklyudova, M.Arlt, P.Brennecke, M.Thelen, A.Gvozdenovic, A.Kuzmanov, B.Robl, S.Botter, W.Born, B.Fuchs. Altered CXCL12 Expression Reveals a Dual Role of CXCR4 in Osteosarcoma Primary Tumor Growth and Metastasis.
    J Cancer Res Clin Oncol Epub ahead of print June 14 2016
  122. Daniel Burger, M.Pumberger, B.Fuchs. An Uncemented Spreading Stem for the Fixation in the Metaphyseal Femur: A Preliminary Report
    Sarcoma May 15, 2016:7132838. Doi:10.1155/2016/7132838
  123. R.Kumar, A.Boro, B.Fuchs. Involvement and Clinical Apsects of microRNA in Osteosarcoma: A Review.
    Int J Mol Sci 2016 Jun 3:17(6)
  124. A. Gvozdenovic, A.Boro, D.Meier, B.Bode-Lesniewska, W.Born, R.Muff, B.Fuchs. Targeting αvβ3 and αvβ5 Integrins Inhibits Pulmonary Metastasis in an Intratibial Xenograft Osteosarcoma Model.
    Oncotarget accepted June 17, 2016
  125. B.Robl, S.Botter, G.Pellegrini, O.Neklyudova, B.Fuchs. Evaluation of Intraarterial and Intravenous Cisplatin Chemotherapy in the Treatment of Metastatic Osteosarcoma using an Orthotopic Xenograft Mouse Model.
    J Exp Clin Cancer Res 35(1):113, 2016
  126. T.Jentzsch, L.Vlachopoulos, P.Fürnstahl, D.Müller, B.Fuchs. Tumor Resection at the Pelvis using Three-dimensional Planning and Patient-specific Instruments: A Case Series.
    World Journal of Surg Oncology accepted Sept 12, 2016
  127. M.Scaglioni, N.Lindenblatt, A.Barth, B.Fuchs, W.Weder, P.Giovanoli. Free Fillet Flap Application to Cover Forequarter or Traumatic Aputation on an Upper Extremity: A Case Report.
    Microsurgery Oct 20, 2016 doi:10.1002/micr.30124.
  128. A.Arteau, B.Fuchs. Complete Deltoid Resection in Infancy results in Normal Shoulder Function at Longterm Followup.
    J Medical Case Reports in print Oct 28, 2016
  129. D.Meier, S.Botter, C.Campanile, B.Robl, S.Gräfe, G.Pellegrini, W.Born, B.Fuchs. Foscan and Foslip based Photodynamic Therapy in Osteosarcoma in vitro and in Intratibial Mouse Models.
    International J Cancer Dec 10, 2016 Epub ahead of print