Orthopädie und
Traumatologie

Prof. Dr.med. et Dr.sc.nat. Bruno Fuchs

Chefarzt, Leiter Orthopädische Tumorchirurgie
Klinik für Orthopädie und Traumatologie

Fax 052 266 45 10

Ausbildungsstellen und klinische Tätigkeit

ab 2017
Chefarzt und Leiter
Orthopädische Tumorchirurgie
Kantonsspital Winterthur

ab 2017
Gründungsmitglied und Senior Consultant
Sarkomboard und Sarkomzentrum
Universitätsspital Zürich

2012 – 2017
Gründungsmitglied und Leiter
Sarkomzentrum und Konsiliarius
Universitätsspital Zürich

2005 – 2016
Leiter
Orthopädische Forschung
Universitätsklinik Balgrist

2005 – 2016
Leitender Arzt
Tumorchirurgie
Universitätsklinik Balgrist

2004
Oberarzt
Universitätsklinik Balgrist

2000 – 2004
Graduate School in Biomedical Sciences
Molecular and Tumor Biology
Mayo College of Medicine, Rochester USA

1998 – 2000
Fellowship
Musculoskeletal Oncology
Mayo Clinic, Rochester USA

1996 – 1998
Assistenzarzt
Orthopädie und Traumatologie
Universitätsklinik Balgrist und Inselspital Bern

1993 – 1995
Assistenzarzt
Allgemeine Chirurgie und Neurochirurgie


Spezialisierung

Abklärung und Behandlung von Knochen- und Weichteiltumoren am Muskuloskelettalen System:

  • Begleitung und Führung von Patienten mit Knochen- und Weichteiltumoren
  • Koordination und Management von Patienten innerhalb der Disziplinen im Rahmen des Sarkomboards
  • Durchführung von Biopsien jeglicher Art in Zusammenarbeit mit den Radiologen
  • Operative Entfernung sowie Rekonstruktion von gut- und bösartigen Knochentumoren des Muskuloskelettalen Systems (inkl. Osteosarkom, Ewing’s Sarkom, und Chondrosarkom) von Kindern und Erwachsenen
  • Operative Entfernung und wenn nötig Rekonstruktion von gut- und bösartigen Tumoren der Weichteile von Kindern und Erwachsenen (Muskelgewebe, Fettgewebe, Gefässe und Nerven etc) des Muskuloskelettalen Systems (inkl. pleomorphe Sarkome; Liposarkome etc)

Ausbildung

2004
Abschluss (Tumor-)Molekularbiologie Studium
Mayo Graduate School

1997
USLME I / II
United States Medical Licensing Examination

1992
Abschluss Medizin Studium
Medizinische Fakultät Zürich


Akademische Stellung

Professor


Akademische Aktivitäten

  • Drittmittel Grants
    Insgesamt mehr als 10 Mio sFr (u.a. von EuroNanoMed)
  • Schweizerischer Nationalfonds (SNF)
  • HSM Programm for Muskuloskelettale Onkologie des Kantons Zürich (Zürcher Krebsliga)
  • Reviewer für SNF (Schweizerische, Deutsche und Zürcher Krebsliga, sowie mehr als 40 internationale perr-reviewed Journals seit 2008 (u.a. Nature, Cancer Research; J Cell Mol Medicine; J Nuclear Medicine)

Präsentationen seit 2008

  • 132 an nationalen Meetings
  • 51 an internationalen Meetings
  • 59 eingeladene Präsentationen

Diplome und Ernennungen

2017
Professor
Universität Zürich

2010
Extraordinarius
Medizinische Fakultät
Universität Zürich

2005
Assistenzprofessor
Medizinische Fakultät
Universität Zürich

2005
Facharzt FMH
Orthopädische Chirurgie und Traumatologie des Bewegungsapparates

2004
PhD Dissertation
Biomedical Sciences and Tumor Biology
Mayo Graduate School, Mayo College of Medicine, Rochester USA

2000
Assistant Professor
Department of Orthopedics
Mayo Clinic, Rochester USA

1999
Instructor
Department of Orthopedics
Mayo Clinic, Rochester USA

1993
MD Dissertation
Universität Zürich


Preise/Ehrungen

2015
Maurice E.Müller Research Prize
presented at the 75th Meeting
For the study: “Prognostic Value and In-vitro Biological Relevance of Neuropilin 1 and Neuropilin-2 in Osteosarcoma”
Swiss Society of Orthopedic Surgeons (SwissOrthopaedics)
Basel, Switzerland

2012
Basic Research Award 2012
For the study on: “Cyr61 indicates Poor Survival in Osteosarcoma Patients and Promotes Intratibial Xenograft Primary Tumor Growth and Lung Metastasis in Mice”
Swiss Bone and Mineral Research Society (SBMS)

2011  
Travelling Fellowship Award (student) of the International Skeletal Society (ISS)
For the Special Scientific Session and for the study: “Evaluation of the Diagnostic Power of Six PET Tracers in an Orthotopic Intratibial Osteosarcoma Mouse Model”
Meeting in San Diego, CA USA

2008 
Best Presentation at the 14th Annual Meeting
For the study: “Cyr61 Expression in Human Osteosarcoma Correlates with Tumor Metastasis”
Swiss Bone and Mineral Society
Davos, Switzerland

2008  
The 2008/2009 Limb Preservation Foundation Pilot Research Grant Award
For the study: “Assessment of Intraarterial Chemotherapy in an Osteosarcoma Mouse Model of Spontaneous Metastasis.”
The Limb Preservation Foundation, Denver, USA

2007  
1st Place and Best “First Time Presentation of a Resident”
For the study: “Rare Diaphyseal Lesions of the Ulna: Surgical Treatment Considerations”
Swiss Orthopedic Society
Montreux, Switzerland

2004   
EW.Johnson Award of the Mid-America Orthopaedic Association
For the study: “Operative Management of Sacro-coccygeal Chordoma”

2003  
Fellowship Award (EFORT-ZIMMER AWARD)
For Orthopaedic Surgery
Offered by the European Federation of National Associations of Orthopaedics and Traumatology and Zimmer
Young Investigator Career Development

2002  
One-Year-Scholarship
Swiss Society of Orthopedic Surgeons

2001 
One-Year-Scholarship
Swiss Society of Orthopedic Surgeons

2001  
Jubiläumspreis
Swiss Radiological Society
Painful Lumbar Disc Derangement: Relevance of Endplate Abnormalities at MR imaging

1999
Patrick J.KELLY Basic Research Award (special fellows category) of the Department of Orthopedics
For the study: “Development of Genetic Landmarks for Comparative Expression Genomics of Osteogenic Sarcoma”
Mayo Clinic and Foundation

1998   
Charles S. NEER Award (Clinical Category)
for the study: “The Clinical and Structural Results of Direct Repair of Massive Tears of the Rotator Cuff”
American Society of Shoulder and Elbow Surgeons ASES


Mitgliedschaften

  • SwissOrthopaedics
  • FMH (Foederatio Medici Helveticorum)
  • Mayo Clinic Orthopedic Alumni Association
  • IVINS Society; FH-Sim Society
  • CTOS (Connective Tissue Oncology Society)
  • MSTS (Musculoskeletal Tumor Society)
  • EMSOS (European Musculoskeletal Oncology Society)
  • ISS (International Skeletal Society)
  • Swiss MD-PhD Society

(Stand Dezember 13, 2016: H-index 36; citations 5225; Google scholar)

  1. B. Fuchs, D. Weishaupt, M. Zanetti, J. Hodler, C. Gerber.  Fatty degeneration of
    the muscles of the rotator cuff:  Assessment by CT versus MR Imaging.
    J Shoulder Elbow Surg  Vol 6 Nov-Dec, 8:599-605, 1999
  2. B. Fuchs, K. Zhang, MG Rock, ME Bolander, G. Sarkar.  Repeat cDNA synthesis and RT-PCR with the same source of RNA.
    Molecular Biotechnology Vol 12:231-235, 1999
  3. B. Fuchs, K. Zhang, MG Rock, ME Bolander, G. Sarkar.  High temperature
    cDNA synthesis by AMV reverse transcriptase improves the specificity of PCR.
    Molecular Biotechnology Vol 12:237-240, 1999
  4. B. Fuchs, B. Jost, C. Gerber.  Posterior Inferior Capsular Shift for the Treatment of Recurrent, Voluntary Posterior Shoulder Subluxation.
    J Bone Joint Surg-Am. 82A:16-25, 2000
  5. C. Gerber, B. Fuchs, J. Hodler.  The Results of the Repair of Massive Tears of the Rotator Cuff.
    J Bone Joint Surg-Am. 82A: 505-515, 2000
  6. B. Fuchs, K.Zhang, ME Bolander, G. Sarkar.  Identification of differentially expressed genes by mutually subtracted RNA fingerprinting.
    Analytical Biochem Nov 286(1):91-98, 2000
  7. B. Fuchs, K.Zhang, ME Bolander, G. Sarkar.  Differential mRNA fingerprinting by preferential amplification of coding sequences.
    Gene   258:155-163, 2000
  8. B. Fuchs, AM Davis, JS. Wunder, RS Bell, BA Masri, B. Isler, R. Turcotte, MG  Rock.  Sciatic nerve resection in the thigh: A functional evaluation
    Clin Orthop  382: 34-41, 2001
  9. D. Weishaupt, M.Zanetti, Hodler J, K.Min, B. Fuchs, CW Pfirrmann, N. Boos. Painful lumbar disk derangement: Relevance of endplate abnormalities at MR imaging.
    Radiology 218(2):420-427, 2001
  10. B.Fuchs, K.Zhang, A.Schabel, ME Bolander, G.Sarkar: Identification of twenty-two candidate genetic markers for osteogenic sarcoma
    Gene  278:245-252, 2001
  11. B.Fuchs, MJ.Yaszemski, FH.Sim: Resection of the Posterior Pelvis and Lumbar Spine for Sarcoma.
    Clin Orthop  397:12-18, 2002
  12. Todd LT, Yaszemski MJ, Currier BL, Fuchs B, Kim CW, MB.Dekutoski, Sim FH. Bowel and Bladder Function following Major Sacral Resection.
    Clin Orthop 397:36-39, 2002
  13. Talac R, Yaszemski MJ, Currier BL, Fuchs B, Dekutoski MB, Kim CW, Sim FH. Relationship between surgical margins and local recurrence in sarcomas of the spine.
    Clin Orthop 397:127-32, 2002
  14. B.Fuchs, DJ.Pritchard. Etiology of Osteosarcoma.*
    Clin Orthop 397:40-52, 2002 
    *specifically noted as highlight in editorial comment: Clin Orthop 397:2, 2002
  15. B.Fuchs, MI.O’Connor, KR.Kaufman, DJ Padgett, FH.Sim. Iliofemoral arthrodesis and Pseudarthrosis: A functional long-term outcome evaluation.
    Clin Orthop 397:29-35, 2002
  16. K.Zhang, N.Dion, B.Fuchs, T.Damron, S.Gitelis, R.Irwin, M.O’Connor, H.Schwartz, SP.Scully, MG.Rock, ME.Bolander, G.Sarkar. The hSEP1 is a novel candidate tumor suppressor gene in osteogenic sarcoma.
    Gene  298:121-127, 2002
  17. B.Fuchs, U.Knothe, R.Hertel, R.Ganz. Femoral Osteotomy and Iliac Graft Vascularization for Femoral Head Osteonecrosis.
    Clin Orthop 412:84-93, 2003
  18. B.Fuchs, C.Inwards, R.Janknecht. Upregulation of the matrix metalloproteinase- gene by the Ewing’s sarcoma associated EWS-ER81 and EWS-Fli1 oncoproteins, c-Jun and p300.
    FEBS Letters  553:104-108, 2003
  19. B.Fuchs, R.Valenzuela, FH.Sim. Pathologic Fracture as a Complication in the Treatment of Ewing’s Sarcoma.
    Clin Orthop 415: 25-30, 2003
    *specifically highlighted in editorial comment: Clin Orthop 415:2-3, 2003
  20. B.Fuchs, BR.Kotajarvi, K.Kaufman, FH.Sim. Functional Outcome of Patients with Rotationplasty about the knee.
    Clin Orthop 415: 52-58, 2003
    *specifically highlighted in editorial comment: Clin Orthop 415:2-3, 2003
  21. B.Fuchs, R.Valenzuela, CS. Arndt, IA.Petersen, FH.Sim. Ewing’s sarcoma and the Development of Secondary Malignancies.
    Clin Orthop 415: 82-89, 2003
    *specifically highlighted in editorial comment: Clin Orthop 415:2-3, 2003
  22. B.Fuchs, R.Valenzuela, C.Inwards, FH.Sim, MG.Rock: Complications in Long-term Survivors of Ewing’s sarcoma.
    Cancer  98(12):2687-92, 2003
  23. B.Fuchs, C.Inwards, R.Janknecht: VEGF expression is Upregulated by EWS-ETS Oncoproteins and Sp1 and may Represent an Independent Predictor of Survival in Ewing’s sarcoma.
    Clin Cancer Res 10:1344-1353, 2004
  24. EY.Chao, B.Fuchs, CM.Rowland, DM.Illstrup, DJ.Pritchard, FH.Sim. Long-term Results of Segmental Prosthesis Fixation by Extra-Cortical Bone Bridging and Ingrowth.
    J Bone Joint Surg Am 86:948-955, 2004
  25. B.Fuchs, FH.Sim. Rotationplasty about the Knee: Surgical Technique and Anatomical Considerations.
    Clin Anat 17(4):345-353, 2004
  26. B.Fuchs, C.Inwards, SP.Scully, R.Janknecht. hTERT is Highly Expressed in Ewing’s Sarcoma and Activated by EWS-ETS Oncopoteins.
    Clin Orthop 426:64-68, 2004
  27. I.Dickey, P.Rose, B.Fuchs, D., Okuno, S, Wold L, FH.Sim, SP.Scully. Dedifferentiated Chondrosarcoma: Updated Ouctomes with Current Treatment Approaches.
    J Bone Joint Surg 86-Am 11:2412-2418, 2004
  28. FH.Sim, B.Fuchs, DJ.Jacofsky. Innovations in Musculoskeletal Oncologic Surgery over the Year 2000.
    Chir Organi Mov 89(3):181-190, 2004
  29. B. Fuchs, RT.Trousdale, MG. Rock.  Solitary Bony Metastasis from Renal Cell Carcinoma: Significance of Surgical Treatment.
    Clin Orthop 431:187-192, 2005
  30. B.Fuchs, SP.Steinmann, AT.Bishop: Free Vascularized Corticoperiosteal Bone Graft for the Treatment of Persistent Nonunion of the Clavicle.
    J Shoulder Elbow Surg 14(3):264-268, 2005
  31. B.Fuchs, MI.O’Connor, DJ.Padget, KR.Kaufman, FH.Sim: Arthrodesis of the Shoulder after Tumor Resection
    Clin Orthop 436:202-207, 2005
  32. B.Fuchs, ID.Dickey, MJ.Yaszemski, C.Inwards, FH.Sim. Operative Management of Sacral Chordoma
    J Bone Joint Surg 87-Am 10:2211-2216, 2005
  33. ID.Dickey, RR.Hugate, B.Fuchs, MJ.Yaszemski, FH.Sim: Reconstruction after Total Sacrectomy: Early Experience with a New Surgical Technique
    Clin Orthop 438:42-50, 2005
  34. B.Fuchs, RJ.Spinner, MG.Rock: MPNST Malignant Peripheral Nerve Sheath Tumors: An update
    J Surg Orthop Adv 14:168-174, 2005
  35. B.Fuchs, MK.Gilbart, J.Hodler, C.Gerber: The Clinical and Structural Results of Open Repair of an Isolated One-tendon Tear of the Rotator Cuff.
    J Bone Joint Surg 88-Am 2:309-316, 2006
  36. SF.Fucentese, A.von Roll, PP.Koch, DR.Epari, B.Fuchs, PB.Schoettle: The Patella Morphology in Trochlear Dysplasia – A Comparative MRI Study.
    Knee 13:145-150, 2006
  37. A. Srivastava*, B.Fuchs*, K.Zhang, M.Ruan, C.Halder, E.Mahlum, K.Weber, ME.Bolander, G.Sarkar: High WT1 Expression is Associated with poor survival of patients with Osteogenic sarcoma metastasis.
    Clin Cancer Res 12(14): 4237-4243, 2006*Co-First-Authorship
  38. C.Ossendorf, B.Fuchs, P.Koch: Femoral Stress Fracture after Computer Navigated Total Knee Arthroplasty.
    Knee 13(5):397-399, 2006
  39. F.Mueller, B.Fuchs, B.Kaser: Comparative Biology of Human and Canine Osteosarcoma
    Anticancer Res 27(1A):155-164, 2007
  40. D.Walters, R.Muff, B.Langsam, P.Gruber, W.Born, Fuchs B: Taurolidine: A novel Anti-neoplastic Agent induces Apoptosis of Osteosarcoma Cell Lines.
    Invest New Drugs 25(4):305-12, 2007
  41. B.Fuchs, E.Mahlum, C.Halder, A.Maran, M.Yaszemski, B.Bode, M.Bolander, G.Sarkar: High Expression of Tumor Endothelial Marker 7 is associated with Metastasis and poor Survival of Patients with Osteogenic Sarcoma.
    Gene  399(2):137-143,  2007
  42. R.Muff, N.Nigg, P.Gruber, D.Walters, W.Born, B.Fuchs: Altered Morphology, Nuclear Stability and Adhesion of Highly Metastatic Derivatives of Osteoblast-like SaOS-2 Osteosarcoma Cells
    Anticancer Res  27(6B): 3973-3979, 2007
  43. N.Bodmer, DK.Walters, B.Fuchs: Pemetrexed, a Multitargeted Antifolate Drug, Demonstrates Lower Efficacy in Comparison to Methotrexate against Osteosarcoma Cell Lines.
    Pediatr Blood Cancer 50(4):905-8, 2008
  44. K.Husmann, R.Muff, W.Born, ME.Bolander, G.Sarkar, B.Fuchs: Cathepsins and Osteosarcoma: Expression Analysis identifies Cathepsin K as a Prognostic Indicator of Metastasis.
    Mol Carcinog 47:66-73, 2008
  45. HA.Ruediger, B.Fuchs, A.von Campe, C.Gerber: Measurements of Shoulder Mobility by Patient and Surgeon Correlate Poorly: A Prospective Study.
    J Shoulder Elbow Surg 17(2):255-60, 2008
  46. DK.Walters, P.Steinmann, B.Langsam, S.Schmutz, W.Born, B.Fuchs: Identification of Potential Chemoresistance Genes in Osteosarcoma
    Anticancer Res 28:673-80, 2008
  47. DK.Walters, R.Muff, B.Langsam, W.Born, B.Fuchs: Cytotoxic Effects of Curcumin on Osteosarcoma Cell Lines
    Invest New Drugs 26:289-97, 2008
  48. B.Fuchs, C.Ossendorf, T.Leerapun, FH.Sim: Intercalary Segmental Reconstruction for Bone Defects.
    Europ J Surgical Oncol 34(12):1271-6, 2008
  49. B.Fuchs, M.Zumstein, F.Regenfelder, P.Steinmann, T.Fuchs, K.Husmann, J.Hellermann, B.Jost, J.Hodler, W.Born, C.Gerber. Upregulation of alpha-skeletal muscle actin and myosin heavy polypeptide gene products in degenerating rotator cuff muscles.
    J Orthop Res 26:1007-11, 2008
  50. C.Ossendorf, GM.Studer, B.Bode, B.Fuchs: Sclerosing Epithelioid Fibrosarcoma: Case Presentation and a Systematic Review
    Clin Orthop Rel Res 466:1485-1491, 2008
  51. S.Schmutz, T.Fuchs, F.Regenfelder, P.Steinmann, M.Zumstein, B.Fuchs. Expression of Atrophy mRNA relates to Tendon Tear Size in Supraspinatus Muscle.
    Clin Orthop Rel Res  467(2):457-464, 2009
  52. E.Frey, F.Regenfelder, P.Sussmann, M.Zumstein,  C.Gerber, W.Born, B.Fuchs: Adipogenic and Myogenic Gene Expression in Rotator Cuff Muscle of the Sheep after Tendon Tear.
    J Orthop Res 27(4):504-509, 2009
  53. B.Fuchs, N.Hoekzema, D.Larson, C.Inwards, FH.Sim: Osteosarcoma of the Pelvis: Outcome Analysis of Surgical Treatment.
    Clin Orthop Rel Res 467(2):510-518, 2009
  54. J.Yuan, C.Ossendorf, JP.Szatkowski, J.Bronk, A.Maran, M.Yaszemski, ME.Bolander, G.Sarkar, B.Fuchs: Osteoblastic and Osteolytic Human Osteosarcomas can be studied with a New Xenograft Mouse Model Producing Spontaneous Metastases
    Cancer Invest  27(4):435-42, 2009
  55. R.Hudek, S.Schmutz, F.Regenfelder, B.Fuchs, PP.Koch. Novel Measurement Technique of the Tibial Slope on Conventional MRI.
    Clin Orthop Rel Res 467:2066-72, 2009
  56. B.Fuchs, W.Born. Molecular and Cellular Mechanisms of Osteosarcoma Metastasis: Current Knowledge and Perspectives (Review)
    Current Orthopaedic Practice 20(6):593-597, 2009
  57. C.Halder, C.Ossendorf, A.Maran, M.Yaszemski, B.Fuchs, G.Sarkar. Preferential Expression of the Secreted and the Membrane Forms of Tumor Endothelial Marker 7 Transcripts in Osteosarcoma.
    Anticancer Res 29(11):4317-22, 2009
  58. C. Ossendorf, GU.Exner, B.Fuchs. A New Incision Technique to Reduce Tibiofemoral Mismatch in Rotationplasty.
    Clin Orthop Rel Res 468:1264-1268, 2010
  59. P.Zwolak, P.Kuehnel, B.Fuchs. Extra-articular Knee Resection for Sarcomas with Preservation of the Extensor Mechanism: Surgical Considerations and Review of Cases
    Clin Orthop Rel Res 469:251-256, 2011
  60. A.Krieg, F.Hefti, B.Speth, L.Guillou, G.Jundt, U.Exner, A.v.Hochstetter, M.Cserhati, B.Fuchs, E.Moushine, A.Kaelin, F.Klenke, K.Siebenrock. Synovial Sarcomas usually Metastasize after  > five Years: A Multicenter, Retrospective Analysis with Minimum Followup of 10 Years for Survivors
    Annals of Oncology 22(2):458-67, 2011
  61. PP.Koch, B.Fuchs, DC. Meyer, SF.Fucentese. Closing Wedge Patellar Osteotomy in Combination with Trochleoplasty.
    Acta Orthop Belg 77(1):116-121, 2011
  62. MJE. Arlt, IJ. Banke, DK. Walters, G. Puskas, P. Steinmann, R. Muff, W. Born, B. Fuchs. LacZ Transgene Expression in the Subcutaneous Dunn / LM8 Osteosarcoma Mouse Model Allows for the Identification of Micrometastasis
    J Orthop Res 29(6):938-46, 2011
  63. R.Hudek, B.Fuchs, F.Regenfelder, PP.Koch. Is Non-contact ACL Injury Associated with the Posterior Tibial and Meniscal Slope?
    Clin Orthop Rel Res 469:2377-84, 2011
  64. B.Fuchs: Current Trends in Musculoskeletal Oncology
    Leading Opinions Orthopädie & Rheumatologie  3:22-24, 2011
  65. P.Steinmann, DK.Walters, MA.Arlt, I.Banke, U.Ziegler, B.Langsam, J.Arbiser, R.Muff, W.Born, B.Fuchs: Antimetastatic Activity of Honokiol in Osteosarcoma.
    Cancer 118(8):2117-27, 2012
  66. A.Sabile, M.Arlt, R.Muff, B.Bode, B.Langsam, J.Bertz, T.Jentzsch, G.Puskas, W.Born, B.Fuchs: Cyr61 indicates Poor Survival in Osteosarcoma Patients and Promotes Intratibial Xenograft Primary Tumor Growth and Lung Metastasis in Mice.
    J Bone Mineral Res 27(1):58-67, 2012
  67. MJE. Arlt, DK. Walters, IP.Banke, P. Steinmann, GJ. Puskas, J.Bertz, K.Rentsch, F.Ehrensperger, W. Born, B. Fuchs. The Antineoplastic Antibiotic Taurolidine Promotes Lung and Liver Metastases in Two Syngeneic Osteosarcoma Mouse Models and Exhibits Severe Liver Toxicity.
    Int J Cancer 131(5):E804-12, 2012 doi: 10.1002/ijc.27378
  68. M.Betz, C.Dumont, B.Fuchs, GU.Exner. Epiphyseal Distraction for Joint Preservation in Malignant Metaphyseal Bone Tumors in Children.
    Clin Orthop Rel Res 470(6):1749-54, 2012
  69. K.Reidy, C.Campanile, R.Muff, W.Born, B.Fuchs. mTHPC-mediated Photodynamic Therapy is Effective in the Metastatic Human 143B Osteosarcoma Cells.
    Photochemistry and Photobiology 88(3):721-7, 2012
  70. M.Erschbamer, B.Bode, FM.Buck, B.Fuchs. A Rare Periosteal Diaphyseal Lesions of the Ulna.
    Open Orthop J 6:8-10, 2012
  71. K.Modaressi, F.Niggli, B.Fuchs. Strategisches Vorgehen bei Verdacht auf Knochensarkom.
    Schweizerische Zeitschrift für Onkologie SZO 2: 12-17, 2012
  72. K.Berndt, J.Vogel, C.Bühler, P.Vogt, W.Born, B.Fuchs. A New Method for Repetitive Drug Infusion into the Femoral Artery of Mice.
    J Am Assoc Lab Animal Science 51(6):825-31, 2012
  73. G.Studer, B.Bode, B.Fuchs. Extremitäten-Weichteilsarkom des Erwachsenen: Stellenwert der Radiotherapie
    Info @ Onkologie 02:14-17, 2012
  74. MJE.Arlt, W.Born, B.Fuchs. Taurolidine: Mode of Administration in Mouse Tumor Models
    Int J Cancer 131(5):E1053-4, 2012 doi:10.1002/ijc.27569
  75. K.Modaressi, B.Fuchs. Die Chirurgische Behandlung von Sarkomen
    Leading Opinions Hämatologie & Onkologie 2:74-76, 2012
  76. M.Arlt, W.Born, B.Fuchs. Improving Visualization of Lung Metastases by Combining X-Gal Staining of LacZ-tagged Tumor Cells with In-situ Perfusion and Fixation of the Lung Tissue
    J Vis Exp (66):e4162, 2012 DOI 10.3791/4162
  77. R.Muff, R.Kumar, S.Botter, W.Born, B.Fuchs: Genes Regulated in Metastatic Osteosarcoma: Evaluation by Microarray Analysis in Four Human and Two Mouse Cell Line Systems.
    Sarcoma 2012; 2012:937506 DOI 10.1155/2012/937506
  78. M.Glanzmann, B.Fuchs, H.Schwyzer. Chronische Ellbogenschmerzen einer Volleyballerin.
    Arthroskopie 1-4, 2012 DOI 10.1007/s00142-012-0711-2
  79. A.Gvozdenovic, MJE. Arlt, C.Campanile, P.Brennecke, K.Husmann, Y. Li, W.Born, R.Muff, B.Fuchs. CD44 Enhances Tumor Formation and Lung Metastasis in Experimental Osteosarcoma and is an Additional Predictor for Poor Patients’ Outcome.
    J Bone Min Res 28(4):838-47, 2013
  80. K.Husmann, MJE.Arlt, R.Muff, B.Langsam, J.Bertz, W.Born, B.Fuchs. Matrix Metalloproteinase 1 promotes Tumor Formation and Lung Metastasis in an Intratibial Injection Osteosarcoma Mouse Model.
    BBA Molecular Basis of Disease 1832(2):347-54, 2013
  81. T.Jentzsch, M.Erschbamer, F.Seeli, B.Fuchs. Extensor Function After Medial Gastrocnemius Flap Reconstruction of the Proximal Tibia.
    Clin Orthop Rel Res 471(7):2333-9, 2013
  82. C.Campanile, M.Arlt, A.Gvozdenovic, P.Brennecke, A.Sabile, M.Honer, C.Fischer, A.Mueller, S. Ametamey, S.Krämer, R.Schibli, W.Born, B.Fuchs. Characterization of Different Osteosarcoma Phenotypes by PET Imaging in Preclinical Animal Models
    J Nuclear Medicine 54(8):1362-8, 2013
  83. K.Modaressi, B.Fuchs, P.Bode, R.Sutter, M.Decurtins, U.Weber. Osteoblastoma of the Ilium mimicking sacroiliitis.
    Arthritis Rheum 65(6):1674, 2013
  84. A.Gozdenovic, MJE.Arlt, C.Campanile, P.Brennecke, K.Husmann, W.Born, R.Muff, B.Fuchs: Silencing of CD44 Gene Expression in Human 143-B Osteosarcoma Cells Promotes Metastasis of Intratibial Tumors in SCID Mice
    PLosOne 8(4):e60329, 2013
  85. K.Berndt, C.Campanile, R.Muff, E.Strehler, W.Born, B.Fuchs. Evaluation of Quercetin as a Potential Drug in Osteosarcoma Treatment.
    Anticancer Res 33(4):1297-306, 2013
  86. A.Sabile, M.Arlt, R.Muff, B.Bode, B.Langsam, J.Bertz, T.Jentzsch, W.Born, B.Fuchs: Caprin1 promotes Metastasis in an Experimental Animal Model of Osteosarcoma.
    BBA Molecular Basis of Disease 1832(8):1173-82, 2013
  87. S.Crivelli-Ochsner, B.Bode, Y.Nussbaumer-Ochsner, B.Fuchs. Giant Cell Angioblastoma in an Adult: A Unique Presentation.
    Rare Tumors 5e27:98-100, 2013
  88. K.Modaressi, G.Studer, B.Bode, S.Hofer, B.Fuchs. Knochenmetastasen – Abklärung und Therapie. Schlaglicht Schweizerische Aertzte Zeitung, Frühjahr 2013.
    Swiss Med Forum 13(2930):571-79, 2013
  89. K.Wieser, K.Modaressi, F.Seeli, B.Fuchs. Autologous Double-Barrel Vascularized Fibular Bone Graft for Arthrodesis of the Shoulder after Tumor Resection.
    Archives Orthop Traumatol 133(9):1219-24, 2013
  90. P.Brennecke, MA Arlt, R.Muff, C.Campanile, A.Gvozdenovic, K.Husmann, N.Holzwarth, E.Cameroni, F.Ehrensperger, M.Thelen, W.Born, B.Fuchs. Expression of the Chemokine Receptor CXCR7 in CXCR4-Expressing Human 143B Osteosarcoma Cells Enhances Lung Metastases of Intratibial Xenografts in SCID Mice.
    PLosOne  8(9):e74045, 2013
  91. MJE.Arlt, IJ.Banke, J.Bertz, R.Mohan, R.Muff, W.Born, B.Fuchs. Reduced Latency in the Metastatic Niche Contributes to the More Aggressive Phenotype of LM8 Compared to Dunn Osteosarcoma Cells.
    Sarcoma 2013; 2013:404962 doi: 10.1155/2013/404962
  92. D.Meier, C.Campanile, S, Botter, W.Born, B.Fuchs. Cytotoxic Efficacy of Photodynamic Therapy in osteosarcoma Cells in vitro.
    J Vis Exp 2014 Mar 18; (85). Doi:10.3791/51213
  93. P.Brennecke, M.Arlt, K.Husmann, C.Campanile, A.Gvozdenovic, T.D’Apuzzo, M.Thelen, W.Born, B.Fuchs. CXCR4 Antibody Treatment Suppresses Metastatic Spread to the Lung of Intratibial Human Osteosarcoma Xenografts In Mice.
    Clin Exp Metastasis 31(3):339-49, 2014
  94. C.Pauli, B.Fuchs, C.Pfirrmann, JA.Bridge, S.Hofer, B.Bode: Response of an Aggressive Periosteal Aneurysmal Bone Cyst (ABC) of the Radius to Denosumab Therapy.
    World J Surg Oncol 12(1): 17, 2014  Doi: 10.1186/1477-7819-12-17 (IF 1.092)
  95. K.Modaressi, P.Giovanoli, P.Schneider, T.Sulser, C.Werner, B.Bode, B.Fuchs. Rezidivierendes Rektumkarzinom: Sakrektomie mit kompletter dorsaler Exenteration.
    Leading Opinions Orthopedics & Rheumatology 1/14:46-8, 2014
  96. S.Botter, D.Neri, B.Fuchs. Recent Advances in Osteosarcoma.
    Curr Opin Pharmacol 16C:15-23, 2014
  97. NR.Datta, E.Puric, R.Schneider, B.Fuchs, S.Bodis, D.Weber. HYPROSAR: Hyperthermia and Proton Radiotherapy in Soft Tissue Sarcoma.
    Leading Opinions Hämatologie & Onkologie 2:158-60, 2014
  98. M.Arlt, I.Banke, D.Walters, K.Berndt, E.Strehler, W.Born, B.Fuchs. The Use of LacZ-transduced Tumor Cells Enhances the Sensitivity of Micrometastasis Detection: A Comparative Study of Gemcitabine Treatment Efficacy in the Mouse LM8 Osteosarcoma Cell Model.
    J Cancer Res Ther 2(6):89-95, 2014
  99. T.Jentzsch, B.Robl, M.Husmann, B.Bode, B.Fuchs. Worse Prognosis of Osteosarcoma Patients expressing IGF-1 on a Tissue Microarray
    Anticancer Res 34(8):3881-9, 2014
  100. RMR. Kumar, MM.Betz, B.Robl, W.Born, B.Fuchs. ΔNp63alpha Exerts Its Oncogenic Potential via Transcriptionally Regulating GLI2 in Osteosarcoma Cells.
    BMC Cancer 14: 559, 2014
  101. M.Rimann, S.Laternser, A.Gvozdenovic, R.Muff, B.Fuchs, J.Kelm, U.Graf-Hausner. An In-vitro Osteosarcoma 3D Microtissue Model for Drug Development.
    J Biotechnology 189C:129-135, 2014
  102. T.Jentzsch, B.Robl, M.Husmann, B.Bode, B.Fuchs. Expression of MSH2 and MSH6 on a Tissue Microarray in Patients with Osteosarcoma.
    Anticancer Res 34(12):6961-72, 2014
  103. B.Fuchs. Research and Development in Tumour Surgery: The Importance of Team Work.
    Swiss Cancer Research Foundation 1:95-99, 2014
  104. R.Cathomas, C.Rothermundt, B.Bode, B.Fuchs, R.von Moos, M.Schwitter. RANK ligand Blockade with Denosumab in Combination with Sorafenib in Chemorefractory Osteosarcoma: a possible Step forward?
    Oncology 88(4):257-60, 2015
  105. K.Husmann, M.Arlt, P.Jirkof, M.Arras, W.Born, B.Fuchs. Primary Tumour Growth in an Orthotopic Osteosarcoma Mouse Model Is Not Inflenced By Analgesic Treatment with Buprenorphine And Meloxicam.
    Laboratory Animals 49(4):284-93, 2015
  106. B.Robl, C.Pauli, S.Botter, B.Bode, B.Fuchs. Prognostic Value of Tumor Suppressors in Osteosarcoma Before and After Neoadjuvant Chemotherapy.
    BMC Cancer 15(1):379- , 2015
  107. NR.Datta, R.Grobholz, E.Puric, B.Bode, N.Lomax, S.Khan, US. Gaipl, B.Fuchs, S.Bodis. Enhanced Tumour Regression in a Patient of Liposarcoma Treated with Radiotherapy and Hyperthermia: Hint for Dynamic Immunomodulation by Hperthermia.
    Int J Hyperthermia 20:1-4, 2015
  108. A.Boro, M.Arlt, H.Lengnick, B.Robl, M.Husmann, J.Bertz, W.Born, B.Fuchs. Prognostic Value and in-vitro Biological Relevance of Neuropilin 1 and Neuropilin 2 in Osteosarcoma.
    Am J Translational Res 7(3):640-53, 2015
  109. T.Jentzsch, B.Fuchs. Therapie von Sarkomen.
    InFo@Onkologie&Hämatologie 3(5):1-6, 2015
  110. G.Studer, M.Brown, B.Fuchs. Radiotherapie bei Weichteilsarkomen des Erwachsenen: Präoperative und Dosis-Volumen-konformierende Anwendung
    InFo@Onkologie 2:13-15, 2015
  111. S.Hodel, F.Seeli, B.Fuchs. Demographische Analyse von Patienten mit Osteosarkom, Chondrosarkom, Ewing’s Sarkom von einem Sarkomzentrum in der Schweiz.
    PRAXIS Schweizerische Rundschau für Medizin 104(13):673-80, 2015
  112. R.Muff, P.Rath, R.Kumar, K.Husmann, W.Born, M.Baudis, B.Fuchs. Genomic Instability of Osteosarcoma Cell Lines during Long-term in vitro Culture.
    PlosOne 10(5):e0125611, 2015
  113. R.Kumar, B.Fuchs. Hedgehog Signaling Inhibitors as Anti-cancer Agents in Osteosarcoma.
    Cancers  7(2):784-94, 2015
  114. R.Kumar, M.Arlt, B.Robl, A.Kuzmanov, O.Neklyudova, K.Husmann, W.Born, B.Fuchs. Sunitinib Malate (SU-11248) Reduces Intratibial Tumour Burden And Lung Metastasis In a Preclinical Mouse Model Of Osteosarcoma.
    Am J Cancer Res 5(7):2156-68, 2015
  115. K.Husmann, P.Ducommun, A.Sabile, E.Pedersen, W.Born, B.Fuchs. Signal Transduction and Downregulation of C-Met in HGF-stimulated Low and Highly Metastatic Human Osteosarcoma Cell Lines.
    Biochem Biophys Res Commun 464(4):1222-7, 2015
  116. B.Fuchs. Swiss National Sarcoma Advisory Board: Vorstellung des Schweizer Konsensus.
    Leading Opinions Hämatologie&Onkologie 3(15):78-80, 2015
  117. D.Müller, B.Fuchs. Whoops Läsionen bei Weichteilsarkomen.
    InFo@Onkologie&Hämatologie 8:26-29, 2015
  118. M.Ture, J.Barth, F.Angst, A.Aeschlimann, U.Schnyder, N.Zerkiebel, J.Perseus, C.Renner, P.Imesch, B.Fuchs, G.Huber, H.Walt, C.Martin-Soelch, J.Jenewein. Use of Inpatient Rehabilitation for Cancer patients in Switzerland: Who undergoes Cancer Rehabilitation?
    Swiss Medical Weekly December 4, 2015 DOI 10.4414/smw.2015.14214
  119. A.Boro, D.Bauer, W.Born, B.Fuchs. Plasma Levels of MIRNA-155 as a Powerful Diagnostic Marker for Dedifferentiated Liposarcoma.
    Am J Cancer Res 6(2):544-52, 2016
  120. R.Muff, S.Botter, K.Husmann, J.Tchinda, P.Selvam, F.Seeli-Maduz, B.Fuchs. Explant Culture of Sarcoma Patients’ Tissue.
    Lab Invest  DOI:10.1038 April 26, 2016
  121. O.Neklyudova, M.Arlt, P.Brennecke, M.Thelen, A.Gvozdenovic, A.Kuzmanov, B.Robl, S.Botter, W.Born, B.Fuchs. Altered CXCL12 Expression Reveals a Dual Role of CXCR4 in Osteosarcoma Primary Tumor Growth and Metastasis.
    J Cancer Res Clin Oncol Epub ahead of print June 14 2016
  122. Daniel Burger, M.Pumberger, B.Fuchs. An Uncemented Spreading Stem for the Fixation in the Metaphyseal Femur: A Preliminary Report
    Sarcoma May 15, 2016:7132838. Doi:10.1155/2016/7132838
  123. R.Kumar, A.Boro, B.Fuchs. Involvement and Clinical Apsects of microRNA in Osteosarcoma: A Review.
    Int J Mol Sci 2016 Jun 3:17(6)
  124. A. Gvozdenovic, A.Boro, D.Meier, B.Bode-Lesniewska, W.Born, R.Muff, B.Fuchs. Targeting αvβ3 and αvβ5 Integrins Inhibits Pulmonary Metastasis in an Intratibial Xenograft Osteosarcoma Model.
    Oncotarget accepted June 17, 2016
  125. B.Robl, S.Botter, G.Pellegrini, O.Neklyudova, B.Fuchs. Evaluation of Intraarterial and Intravenous Cisplatin Chemotherapy in the Treatment of Metastatic Osteosarcoma using an Orthotopic Xenograft Mouse Model.
    J Exp Clin Cancer Res 35(1):113, 2016
  126. T.Jentzsch, L.Vlachopoulos, P.Fürnstahl, D.Müller, B.Fuchs. Tumor Resection at the Pelvis using Three-dimensional Planning and Patient-specific Instruments: A Case Series.
    World Journal of Surg Oncology accepted Sept 12, 2016
  127. M.Scaglioni, N.Lindenblatt, A.Barth, B.Fuchs, W.Weder, P.Giovanoli. Free Fillet Flap Application to Cover Forequarter or Traumatic Aputation on an Upper Extremity: A Case Report.
    Microsurgery Oct 20, 2016 doi:10.1002/micr.30124.
  128. A.Arteau, B.Fuchs. Complete Deltoid Resection in Infancy results in Normal Shoulder Function at Longterm Followup.
    J Medical Case Reports in print Oct 28, 2016
  129. D.Meier, S.Botter, C.Campanile, B.Robl, S.Gräfe, G.Pellegrini, W.Born, B.Fuchs. Foscan and Foslip based Photodynamic Therapy in Osteosarcoma in vitro and in Intratibial Mouse Models.
    International J Cancer Dec 10, 2016 Epub ahead of print
  • Curriculum vitae

    Ausbildungsstellen und klinische Tätigkeit

    ab 2017
    Chefarzt und Leiter
    Orthopädische Tumorchirurgie
    Kantonsspital Winterthur

    ab 2017
    Gründungsmitglied und Senior Consultant
    Sarkomboard und Sarkomzentrum
    Universitätsspital Zürich

    2012 – 2017
    Gründungsmitglied und Leiter
    Sarkomzentrum und Konsiliarius
    Universitätsspital Zürich

    2005 – 2016
    Leiter
    Orthopädische Forschung
    Universitätsklinik Balgrist

    2005 – 2016
    Leitender Arzt
    Tumorchirurgie
    Universitätsklinik Balgrist

    2004
    Oberarzt
    Universitätsklinik Balgrist

    2000 – 2004
    Graduate School in Biomedical Sciences
    Molecular and Tumor Biology
    Mayo College of Medicine, Rochester USA

    1998 – 2000
    Fellowship
    Musculoskeletal Oncology
    Mayo Clinic, Rochester USA

    1996 – 1998
    Assistenzarzt
    Orthopädie und Traumatologie
    Universitätsklinik Balgrist und Inselspital Bern

    1993 – 1995
    Assistenzarzt
    Allgemeine Chirurgie und Neurochirurgie


    Spezialisierung

    Abklärung und Behandlung von Knochen- und Weichteiltumoren am Muskuloskelettalen System:

    • Begleitung und Führung von Patienten mit Knochen- und Weichteiltumoren
    • Koordination und Management von Patienten innerhalb der Disziplinen im Rahmen des Sarkomboards
    • Durchführung von Biopsien jeglicher Art in Zusammenarbeit mit den Radiologen
    • Operative Entfernung sowie Rekonstruktion von gut- und bösartigen Knochentumoren des Muskuloskelettalen Systems (inkl. Osteosarkom, Ewing’s Sarkom, und Chondrosarkom) von Kindern und Erwachsenen
    • Operative Entfernung und wenn nötig Rekonstruktion von gut- und bösartigen Tumoren der Weichteile von Kindern und Erwachsenen (Muskelgewebe, Fettgewebe, Gefässe und Nerven etc) des Muskuloskelettalen Systems (inkl. pleomorphe Sarkome; Liposarkome etc)

    Ausbildung

    2004
    Abschluss (Tumor-)Molekularbiologie Studium
    Mayo Graduate School

    1997
    USLME I / II
    United States Medical Licensing Examination

    1992
    Abschluss Medizin Studium
    Medizinische Fakultät Zürich


    Akademische Stellung

    Professor


    Akademische Aktivitäten

    • Drittmittel Grants
      Insgesamt mehr als 10 Mio sFr (u.a. von EuroNanoMed)
    • Schweizerischer Nationalfonds (SNF)
    • HSM Programm for Muskuloskelettale Onkologie des Kantons Zürich (Zürcher Krebsliga)
    • Reviewer für SNF (Schweizerische, Deutsche und Zürcher Krebsliga, sowie mehr als 40 internationale perr-reviewed Journals seit 2008 (u.a. Nature, Cancer Research; J Cell Mol Medicine; J Nuclear Medicine)

    Präsentationen seit 2008

    • 132 an nationalen Meetings
    • 51 an internationalen Meetings
    • 59 eingeladene Präsentationen

    Diplome und Ernennungen

    2017
    Professor
    Universität Zürich

    2010
    Extraordinarius
    Medizinische Fakultät
    Universität Zürich

    2005
    Assistenzprofessor
    Medizinische Fakultät
    Universität Zürich

    2005
    Facharzt FMH
    Orthopädische Chirurgie und Traumatologie des Bewegungsapparates

    2004
    PhD Dissertation
    Biomedical Sciences and Tumor Biology
    Mayo Graduate School, Mayo College of Medicine, Rochester USA

    2000
    Assistant Professor
    Department of Orthopedics
    Mayo Clinic, Rochester USA

    1999
    Instructor
    Department of Orthopedics
    Mayo Clinic, Rochester USA

    1993
    MD Dissertation
    Universität Zürich


    Preise/Ehrungen

    2015
    Maurice E.Müller Research Prize
    presented at the 75th Meeting
    For the study: “Prognostic Value and In-vitro Biological Relevance of Neuropilin 1 and Neuropilin-2 in Osteosarcoma”
    Swiss Society of Orthopedic Surgeons (SwissOrthopaedics)
    Basel, Switzerland

    2012
    Basic Research Award 2012
    For the study on: “Cyr61 indicates Poor Survival in Osteosarcoma Patients and Promotes Intratibial Xenograft Primary Tumor Growth and Lung Metastasis in Mice”
    Swiss Bone and Mineral Research Society (SBMS)

    2011  
    Travelling Fellowship Award (student) of the International Skeletal Society (ISS)
    For the Special Scientific Session and for the study: “Evaluation of the Diagnostic Power of Six PET Tracers in an Orthotopic Intratibial Osteosarcoma Mouse Model”
    Meeting in San Diego, CA USA

    2008 
    Best Presentation at the 14th Annual Meeting
    For the study: “Cyr61 Expression in Human Osteosarcoma Correlates with Tumor Metastasis”
    Swiss Bone and Mineral Society
    Davos, Switzerland

    2008  
    The 2008/2009 Limb Preservation Foundation Pilot Research Grant Award
    For the study: “Assessment of Intraarterial Chemotherapy in an Osteosarcoma Mouse Model of Spontaneous Metastasis.”
    The Limb Preservation Foundation, Denver, USA

    2007  
    1st Place and Best “First Time Presentation of a Resident”
    For the study: “Rare Diaphyseal Lesions of the Ulna: Surgical Treatment Considerations”
    Swiss Orthopedic Society
    Montreux, Switzerland

    2004   
    EW.Johnson Award of the Mid-America Orthopaedic Association
    For the study: “Operative Management of Sacro-coccygeal Chordoma”

    2003  
    Fellowship Award (EFORT-ZIMMER AWARD)
    For Orthopaedic Surgery
    Offered by the European Federation of National Associations of Orthopaedics and Traumatology and Zimmer
    Young Investigator Career Development

    2002  
    One-Year-Scholarship
    Swiss Society of Orthopedic Surgeons

    2001 
    One-Year-Scholarship
    Swiss Society of Orthopedic Surgeons

    2001  
    Jubiläumspreis
    Swiss Radiological Society
    Painful Lumbar Disc Derangement: Relevance of Endplate Abnormalities at MR imaging

    1999
    Patrick J.KELLY Basic Research Award (special fellows category) of the Department of Orthopedics
    For the study: “Development of Genetic Landmarks for Comparative Expression Genomics of Osteogenic Sarcoma”
    Mayo Clinic and Foundation

    1998   
    Charles S. NEER Award (Clinical Category)
    for the study: “The Clinical and Structural Results of Direct Repair of Massive Tears of the Rotator Cuff”
    American Society of Shoulder and Elbow Surgeons ASES


    Mitgliedschaften

    • SwissOrthopaedics
    • FMH (Foederatio Medici Helveticorum)
    • Mayo Clinic Orthopedic Alumni Association
    • IVINS Society; FH-Sim Society
    • CTOS (Connective Tissue Oncology Society)
    • MSTS (Musculoskeletal Tumor Society)
    • EMSOS (European Musculoskeletal Oncology Society)
    • ISS (International Skeletal Society)
    • Swiss MD-PhD Society
  • Publikationen

    (Stand Dezember 13, 2016: H-index 36; citations 5225; Google scholar)

    1. B. Fuchs, D. Weishaupt, M. Zanetti, J. Hodler, C. Gerber.  Fatty degeneration of
      the muscles of the rotator cuff:  Assessment by CT versus MR Imaging.
      J Shoulder Elbow Surg  Vol 6 Nov-Dec, 8:599-605, 1999
    2. B. Fuchs, K. Zhang, MG Rock, ME Bolander, G. Sarkar.  Repeat cDNA synthesis and RT-PCR with the same source of RNA.
      Molecular Biotechnology Vol 12:231-235, 1999
    3. B. Fuchs, K. Zhang, MG Rock, ME Bolander, G. Sarkar.  High temperature
      cDNA synthesis by AMV reverse transcriptase improves the specificity of PCR.
      Molecular Biotechnology Vol 12:237-240, 1999
    4. B. Fuchs, B. Jost, C. Gerber.  Posterior Inferior Capsular Shift for the Treatment of Recurrent, Voluntary Posterior Shoulder Subluxation.
      J Bone Joint Surg-Am. 82A:16-25, 2000
    5. C. Gerber, B. Fuchs, J. Hodler.  The Results of the Repair of Massive Tears of the Rotator Cuff.
      J Bone Joint Surg-Am. 82A: 505-515, 2000
    6. B. Fuchs, K.Zhang, ME Bolander, G. Sarkar.  Identification of differentially expressed genes by mutually subtracted RNA fingerprinting.
      Analytical Biochem Nov 286(1):91-98, 2000
    7. B. Fuchs, K.Zhang, ME Bolander, G. Sarkar.  Differential mRNA fingerprinting by preferential amplification of coding sequences.
      Gene   258:155-163, 2000
    8. B. Fuchs, AM Davis, JS. Wunder, RS Bell, BA Masri, B. Isler, R. Turcotte, MG  Rock.  Sciatic nerve resection in the thigh: A functional evaluation
      Clin Orthop  382: 34-41, 2001
    9. D. Weishaupt, M.Zanetti, Hodler J, K.Min, B. Fuchs, CW Pfirrmann, N. Boos. Painful lumbar disk derangement: Relevance of endplate abnormalities at MR imaging.
      Radiology 218(2):420-427, 2001
    10. B.Fuchs, K.Zhang, A.Schabel, ME Bolander, G.Sarkar: Identification of twenty-two candidate genetic markers for osteogenic sarcoma
      Gene  278:245-252, 2001
    11. B.Fuchs, MJ.Yaszemski, FH.Sim: Resection of the Posterior Pelvis and Lumbar Spine for Sarcoma.
      Clin Orthop  397:12-18, 2002
    12. Todd LT, Yaszemski MJ, Currier BL, Fuchs B, Kim CW, MB.Dekutoski, Sim FH. Bowel and Bladder Function following Major Sacral Resection.
      Clin Orthop 397:36-39, 2002
    13. Talac R, Yaszemski MJ, Currier BL, Fuchs B, Dekutoski MB, Kim CW, Sim FH. Relationship between surgical margins and local recurrence in sarcomas of the spine.
      Clin Orthop 397:127-32, 2002
    14. B.Fuchs, DJ.Pritchard. Etiology of Osteosarcoma.*
      Clin Orthop 397:40-52, 2002 
      *specifically noted as highlight in editorial comment: Clin Orthop 397:2, 2002
    15. B.Fuchs, MI.O’Connor, KR.Kaufman, DJ Padgett, FH.Sim. Iliofemoral arthrodesis and Pseudarthrosis: A functional long-term outcome evaluation.
      Clin Orthop 397:29-35, 2002
    16. K.Zhang, N.Dion, B.Fuchs, T.Damron, S.Gitelis, R.Irwin, M.O’Connor, H.Schwartz, SP.Scully, MG.Rock, ME.Bolander, G.Sarkar. The hSEP1 is a novel candidate tumor suppressor gene in osteogenic sarcoma.
      Gene  298:121-127, 2002
    17. B.Fuchs, U.Knothe, R.Hertel, R.Ganz. Femoral Osteotomy and Iliac Graft Vascularization for Femoral Head Osteonecrosis.
      Clin Orthop 412:84-93, 2003
    18. B.Fuchs, C.Inwards, R.Janknecht. Upregulation of the matrix metalloproteinase- gene by the Ewing’s sarcoma associated EWS-ER81 and EWS-Fli1 oncoproteins, c-Jun and p300.
      FEBS Letters  553:104-108, 2003
    19. B.Fuchs, R.Valenzuela, FH.Sim. Pathologic Fracture as a Complication in the Treatment of Ewing’s Sarcoma.
      Clin Orthop 415: 25-30, 2003
      *specifically highlighted in editorial comment: Clin Orthop 415:2-3, 2003
    20. B.Fuchs, BR.Kotajarvi, K.Kaufman, FH.Sim. Functional Outcome of Patients with Rotationplasty about the knee.
      Clin Orthop 415: 52-58, 2003
      *specifically highlighted in editorial comment: Clin Orthop 415:2-3, 2003
    21. B.Fuchs, R.Valenzuela, CS. Arndt, IA.Petersen, FH.Sim. Ewing’s sarcoma and the Development of Secondary Malignancies.
      Clin Orthop 415: 82-89, 2003
      *specifically highlighted in editorial comment: Clin Orthop 415:2-3, 2003
    22. B.Fuchs, R.Valenzuela, C.Inwards, FH.Sim, MG.Rock: Complications in Long-term Survivors of Ewing’s sarcoma.
      Cancer  98(12):2687-92, 2003
    23. B.Fuchs, C.Inwards, R.Janknecht: VEGF expression is Upregulated by EWS-ETS Oncoproteins and Sp1 and may Represent an Independent Predictor of Survival in Ewing’s sarcoma.
      Clin Cancer Res 10:1344-1353, 2004
    24. EY.Chao, B.Fuchs, CM.Rowland, DM.Illstrup, DJ.Pritchard, FH.Sim. Long-term Results of Segmental Prosthesis Fixation by Extra-Cortical Bone Bridging and Ingrowth.
      J Bone Joint Surg Am 86:948-955, 2004
    25. B.Fuchs, FH.Sim. Rotationplasty about the Knee: Surgical Technique and Anatomical Considerations.
      Clin Anat 17(4):345-353, 2004
    26. B.Fuchs, C.Inwards, SP.Scully, R.Janknecht. hTERT is Highly Expressed in Ewing’s Sarcoma and Activated by EWS-ETS Oncopoteins.
      Clin Orthop 426:64-68, 2004
    27. I.Dickey, P.Rose, B.Fuchs, D., Okuno, S, Wold L, FH.Sim, SP.Scully. Dedifferentiated Chondrosarcoma: Updated Ouctomes with Current Treatment Approaches.
      J Bone Joint Surg 86-Am 11:2412-2418, 2004
    28. FH.Sim, B.Fuchs, DJ.Jacofsky. Innovations in Musculoskeletal Oncologic Surgery over the Year 2000.
      Chir Organi Mov 89(3):181-190, 2004
    29. B. Fuchs, RT.Trousdale, MG. Rock.  Solitary Bony Metastasis from Renal Cell Carcinoma: Significance of Surgical Treatment.
      Clin Orthop 431:187-192, 2005
    30. B.Fuchs, SP.Steinmann, AT.Bishop: Free Vascularized Corticoperiosteal Bone Graft for the Treatment of Persistent Nonunion of the Clavicle.
      J Shoulder Elbow Surg 14(3):264-268, 2005
    31. B.Fuchs, MI.O’Connor, DJ.Padget, KR.Kaufman, FH.Sim: Arthrodesis of the Shoulder after Tumor Resection
      Clin Orthop 436:202-207, 2005
    32. B.Fuchs, ID.Dickey, MJ.Yaszemski, C.Inwards, FH.Sim. Operative Management of Sacral Chordoma
      J Bone Joint Surg 87-Am 10:2211-2216, 2005
    33. ID.Dickey, RR.Hugate, B.Fuchs, MJ.Yaszemski, FH.Sim: Reconstruction after Total Sacrectomy: Early Experience with a New Surgical Technique
      Clin Orthop 438:42-50, 2005
    34. B.Fuchs, RJ.Spinner, MG.Rock: MPNST Malignant Peripheral Nerve Sheath Tumors: An update
      J Surg Orthop Adv 14:168-174, 2005
    35. B.Fuchs, MK.Gilbart, J.Hodler, C.Gerber: The Clinical and Structural Results of Open Repair of an Isolated One-tendon Tear of the Rotator Cuff.
      J Bone Joint Surg 88-Am 2:309-316, 2006
    36. SF.Fucentese, A.von Roll, PP.Koch, DR.Epari, B.Fuchs, PB.Schoettle: The Patella Morphology in Trochlear Dysplasia – A Comparative MRI Study.
      Knee 13:145-150, 2006
    37. A. Srivastava*, B.Fuchs*, K.Zhang, M.Ruan, C.Halder, E.Mahlum, K.Weber, ME.Bolander, G.Sarkar: High WT1 Expression is Associated with poor survival of patients with Osteogenic sarcoma metastasis.
      Clin Cancer Res 12(14): 4237-4243, 2006*Co-First-Authorship
    38. C.Ossendorf, B.Fuchs, P.Koch: Femoral Stress Fracture after Computer Navigated Total Knee Arthroplasty.
      Knee 13(5):397-399, 2006
    39. F.Mueller, B.Fuchs, B.Kaser: Comparative Biology of Human and Canine Osteosarcoma
      Anticancer Res 27(1A):155-164, 2007
    40. D.Walters, R.Muff, B.Langsam, P.Gruber, W.Born, Fuchs B: Taurolidine: A novel Anti-neoplastic Agent induces Apoptosis of Osteosarcoma Cell Lines.
      Invest New Drugs 25(4):305-12, 2007
    41. B.Fuchs, E.Mahlum, C.Halder, A.Maran, M.Yaszemski, B.Bode, M.Bolander, G.Sarkar: High Expression of Tumor Endothelial Marker 7 is associated with Metastasis and poor Survival of Patients with Osteogenic Sarcoma.
      Gene  399(2):137-143,  2007
    42. R.Muff, N.Nigg, P.Gruber, D.Walters, W.Born, B.Fuchs: Altered Morphology, Nuclear Stability and Adhesion of Highly Metastatic Derivatives of Osteoblast-like SaOS-2 Osteosarcoma Cells
      Anticancer Res  27(6B): 3973-3979, 2007
    43. N.Bodmer, DK.Walters, B.Fuchs: Pemetrexed, a Multitargeted Antifolate Drug, Demonstrates Lower Efficacy in Comparison to Methotrexate against Osteosarcoma Cell Lines.
      Pediatr Blood Cancer 50(4):905-8, 2008
    44. K.Husmann, R.Muff, W.Born, ME.Bolander, G.Sarkar, B.Fuchs: Cathepsins and Osteosarcoma: Expression Analysis identifies Cathepsin K as a Prognostic Indicator of Metastasis.
      Mol Carcinog 47:66-73, 2008
    45. HA.Ruediger, B.Fuchs, A.von Campe, C.Gerber: Measurements of Shoulder Mobility by Patient and Surgeon Correlate Poorly: A Prospective Study.
      J Shoulder Elbow Surg 17(2):255-60, 2008
    46. DK.Walters, P.Steinmann, B.Langsam, S.Schmutz, W.Born, B.Fuchs: Identification of Potential Chemoresistance Genes in Osteosarcoma
      Anticancer Res 28:673-80, 2008
    47. DK.Walters, R.Muff, B.Langsam, W.Born, B.Fuchs: Cytotoxic Effects of Curcumin on Osteosarcoma Cell Lines
      Invest New Drugs 26:289-97, 2008
    48. B.Fuchs, C.Ossendorf, T.Leerapun, FH.Sim: Intercalary Segmental Reconstruction for Bone Defects.
      Europ J Surgical Oncol 34(12):1271-6, 2008
    49. B.Fuchs, M.Zumstein, F.Regenfelder, P.Steinmann, T.Fuchs, K.Husmann, J.Hellermann, B.Jost, J.Hodler, W.Born, C.Gerber. Upregulation of alpha-skeletal muscle actin and myosin heavy polypeptide gene products in degenerating rotator cuff muscles.
      J Orthop Res 26:1007-11, 2008
    50. C.Ossendorf, GM.Studer, B.Bode, B.Fuchs: Sclerosing Epithelioid Fibrosarcoma: Case Presentation and a Systematic Review
      Clin Orthop Rel Res 466:1485-1491, 2008
    51. S.Schmutz, T.Fuchs, F.Regenfelder, P.Steinmann, M.Zumstein, B.Fuchs. Expression of Atrophy mRNA relates to Tendon Tear Size in Supraspinatus Muscle.
      Clin Orthop Rel Res  467(2):457-464, 2009
    52. E.Frey, F.Regenfelder, P.Sussmann, M.Zumstein,  C.Gerber, W.Born, B.Fuchs: Adipogenic and Myogenic Gene Expression in Rotator Cuff Muscle of the Sheep after Tendon Tear.
      J Orthop Res 27(4):504-509, 2009
    53. B.Fuchs, N.Hoekzema, D.Larson, C.Inwards, FH.Sim: Osteosarcoma of the Pelvis: Outcome Analysis of Surgical Treatment.
      Clin Orthop Rel Res 467(2):510-518, 2009
    54. J.Yuan, C.Ossendorf, JP.Szatkowski, J.Bronk, A.Maran, M.Yaszemski, ME.Bolander, G.Sarkar, B.Fuchs: Osteoblastic and Osteolytic Human Osteosarcomas can be studied with a New Xenograft Mouse Model Producing Spontaneous Metastases
      Cancer Invest  27(4):435-42, 2009
    55. R.Hudek, S.Schmutz, F.Regenfelder, B.Fuchs, PP.Koch. Novel Measurement Technique of the Tibial Slope on Conventional MRI.
      Clin Orthop Rel Res 467:2066-72, 2009
    56. B.Fuchs, W.Born. Molecular and Cellular Mechanisms of Osteosarcoma Metastasis: Current Knowledge and Perspectives (Review)
      Current Orthopaedic Practice 20(6):593-597, 2009
    57. C.Halder, C.Ossendorf, A.Maran, M.Yaszemski, B.Fuchs, G.Sarkar. Preferential Expression of the Secreted and the Membrane Forms of Tumor Endothelial Marker 7 Transcripts in Osteosarcoma.
      Anticancer Res 29(11):4317-22, 2009
    58. C. Ossendorf, GU.Exner, B.Fuchs. A New Incision Technique to Reduce Tibiofemoral Mismatch in Rotationplasty.
      Clin Orthop Rel Res 468:1264-1268, 2010
    59. P.Zwolak, P.Kuehnel, B.Fuchs. Extra-articular Knee Resection for Sarcomas with Preservation of the Extensor Mechanism: Surgical Considerations and Review of Cases
      Clin Orthop Rel Res 469:251-256, 2011
    60. A.Krieg, F.Hefti, B.Speth, L.Guillou, G.Jundt, U.Exner, A.v.Hochstetter, M.Cserhati, B.Fuchs, E.Moushine, A.Kaelin, F.Klenke, K.Siebenrock. Synovial Sarcomas usually Metastasize after  > five Years: A Multicenter, Retrospective Analysis with Minimum Followup of 10 Years for Survivors
      Annals of Oncology 22(2):458-67, 2011
    61. PP.Koch, B.Fuchs, DC. Meyer, SF.Fucentese. Closing Wedge Patellar Osteotomy in Combination with Trochleoplasty.
      Acta Orthop Belg 77(1):116-121, 2011
    62. MJE. Arlt, IJ. Banke, DK. Walters, G. Puskas, P. Steinmann, R. Muff, W. Born, B. Fuchs. LacZ Transgene Expression in the Subcutaneous Dunn / LM8 Osteosarcoma Mouse Model Allows for the Identification of Micrometastasis
      J Orthop Res 29(6):938-46, 2011
    63. R.Hudek, B.Fuchs, F.Regenfelder, PP.Koch. Is Non-contact ACL Injury Associated with the Posterior Tibial and Meniscal Slope?
      Clin Orthop Rel Res 469:2377-84, 2011
    64. B.Fuchs: Current Trends in Musculoskeletal Oncology
      Leading Opinions Orthopädie & Rheumatologie  3:22-24, 2011
    65. P.Steinmann, DK.Walters, MA.Arlt, I.Banke, U.Ziegler, B.Langsam, J.Arbiser, R.Muff, W.Born, B.Fuchs: Antimetastatic Activity of Honokiol in Osteosarcoma.
      Cancer 118(8):2117-27, 2012
    66. A.Sabile, M.Arlt, R.Muff, B.Bode, B.Langsam, J.Bertz, T.Jentzsch, G.Puskas, W.Born, B.Fuchs: Cyr61 indicates Poor Survival in Osteosarcoma Patients and Promotes Intratibial Xenograft Primary Tumor Growth and Lung Metastasis in Mice.
      J Bone Mineral Res 27(1):58-67, 2012
    67. MJE. Arlt, DK. Walters, IP.Banke, P. Steinmann, GJ. Puskas, J.Bertz, K.Rentsch, F.Ehrensperger, W. Born, B. Fuchs. The Antineoplastic Antibiotic Taurolidine Promotes Lung and Liver Metastases in Two Syngeneic Osteosarcoma Mouse Models and Exhibits Severe Liver Toxicity.
      Int J Cancer 131(5):E804-12, 2012 doi: 10.1002/ijc.27378
    68. M.Betz, C.Dumont, B.Fuchs, GU.Exner. Epiphyseal Distraction for Joint Preservation in Malignant Metaphyseal Bone Tumors in Children.
      Clin Orthop Rel Res 470(6):1749-54, 2012
    69. K.Reidy, C.Campanile, R.Muff, W.Born, B.Fuchs. mTHPC-mediated Photodynamic Therapy is Effective in the Metastatic Human 143B Osteosarcoma Cells.
      Photochemistry and Photobiology 88(3):721-7, 2012
    70. M.Erschbamer, B.Bode, FM.Buck, B.Fuchs. A Rare Periosteal Diaphyseal Lesions of the Ulna.
      Open Orthop J 6:8-10, 2012
    71. K.Modaressi, F.Niggli, B.Fuchs. Strategisches Vorgehen bei Verdacht auf Knochensarkom.
      Schweizerische Zeitschrift für Onkologie SZO 2: 12-17, 2012
    72. K.Berndt, J.Vogel, C.Bühler, P.Vogt, W.Born, B.Fuchs. A New Method for Repetitive Drug Infusion into the Femoral Artery of Mice.
      J Am Assoc Lab Animal Science 51(6):825-31, 2012
    73. G.Studer, B.Bode, B.Fuchs. Extremitäten-Weichteilsarkom des Erwachsenen: Stellenwert der Radiotherapie
      Info @ Onkologie 02:14-17, 2012
    74. MJE.Arlt, W.Born, B.Fuchs. Taurolidine: Mode of Administration in Mouse Tumor Models
      Int J Cancer 131(5):E1053-4, 2012 doi:10.1002/ijc.27569
    75. K.Modaressi, B.Fuchs. Die Chirurgische Behandlung von Sarkomen
      Leading Opinions Hämatologie & Onkologie 2:74-76, 2012
    76. M.Arlt, W.Born, B.Fuchs. Improving Visualization of Lung Metastases by Combining X-Gal Staining of LacZ-tagged Tumor Cells with In-situ Perfusion and Fixation of the Lung Tissue
      J Vis Exp (66):e4162, 2012 DOI 10.3791/4162
    77. R.Muff, R.Kumar, S.Botter, W.Born, B.Fuchs: Genes Regulated in Metastatic Osteosarcoma: Evaluation by Microarray Analysis in Four Human and Two Mouse Cell Line Systems.
      Sarcoma 2012; 2012:937506 DOI 10.1155/2012/937506
    78. M.Glanzmann, B.Fuchs, H.Schwyzer. Chronische Ellbogenschmerzen einer Volleyballerin.
      Arthroskopie 1-4, 2012 DOI 10.1007/s00142-012-0711-2
    79. A.Gvozdenovic, MJE. Arlt, C.Campanile, P.Brennecke, K.Husmann, Y. Li, W.Born, R.Muff, B.Fuchs. CD44 Enhances Tumor Formation and Lung Metastasis in Experimental Osteosarcoma and is an Additional Predictor for Poor Patients’ Outcome.
      J Bone Min Res 28(4):838-47, 2013
    80. K.Husmann, MJE.Arlt, R.Muff, B.Langsam, J.Bertz, W.Born, B.Fuchs. Matrix Metalloproteinase 1 promotes Tumor Formation and Lung Metastasis in an Intratibial Injection Osteosarcoma Mouse Model.
      BBA Molecular Basis of Disease 1832(2):347-54, 2013
    81. T.Jentzsch, M.Erschbamer, F.Seeli, B.Fuchs. Extensor Function After Medial Gastrocnemius Flap Reconstruction of the Proximal Tibia.
      Clin Orthop Rel Res 471(7):2333-9, 2013
    82. C.Campanile, M.Arlt, A.Gvozdenovic, P.Brennecke, A.Sabile, M.Honer, C.Fischer, A.Mueller, S. Ametamey, S.Krämer, R.Schibli, W.Born, B.Fuchs. Characterization of Different Osteosarcoma Phenotypes by PET Imaging in Preclinical Animal Models
      J Nuclear Medicine 54(8):1362-8, 2013
    83. K.Modaressi, B.Fuchs, P.Bode, R.Sutter, M.Decurtins, U.Weber. Osteoblastoma of the Ilium mimicking sacroiliitis.
      Arthritis Rheum 65(6):1674, 2013
    84. A.Gozdenovic, MJE.Arlt, C.Campanile, P.Brennecke, K.Husmann, W.Born, R.Muff, B.Fuchs: Silencing of CD44 Gene Expression in Human 143-B Osteosarcoma Cells Promotes Metastasis of Intratibial Tumors in SCID Mice
      PLosOne 8(4):e60329, 2013
    85. K.Berndt, C.Campanile, R.Muff, E.Strehler, W.Born, B.Fuchs. Evaluation of Quercetin as a Potential Drug in Osteosarcoma Treatment.
      Anticancer Res 33(4):1297-306, 2013
    86. A.Sabile, M.Arlt, R.Muff, B.Bode, B.Langsam, J.Bertz, T.Jentzsch, W.Born, B.Fuchs: Caprin1 promotes Metastasis in an Experimental Animal Model of Osteosarcoma.
      BBA Molecular Basis of Disease 1832(8):1173-82, 2013
    87. S.Crivelli-Ochsner, B.Bode, Y.Nussbaumer-Ochsner, B.Fuchs. Giant Cell Angioblastoma in an Adult: A Unique Presentation.
      Rare Tumors 5e27:98-100, 2013
    88. K.Modaressi, G.Studer, B.Bode, S.Hofer, B.Fuchs. Knochenmetastasen – Abklärung und Therapie. Schlaglicht Schweizerische Aertzte Zeitung, Frühjahr 2013.
      Swiss Med Forum 13(2930):571-79, 2013
    89. K.Wieser, K.Modaressi, F.Seeli, B.Fuchs. Autologous Double-Barrel Vascularized Fibular Bone Graft for Arthrodesis of the Shoulder after Tumor Resection.
      Archives Orthop Traumatol 133(9):1219-24, 2013
    90. P.Brennecke, MA Arlt, R.Muff, C.Campanile, A.Gvozdenovic, K.Husmann, N.Holzwarth, E.Cameroni, F.Ehrensperger, M.Thelen, W.Born, B.Fuchs. Expression of the Chemokine Receptor CXCR7 in CXCR4-Expressing Human 143B Osteosarcoma Cells Enhances Lung Metastases of Intratibial Xenografts in SCID Mice.
      PLosOne  8(9):e74045, 2013
    91. MJE.Arlt, IJ.Banke, J.Bertz, R.Mohan, R.Muff, W.Born, B.Fuchs. Reduced Latency in the Metastatic Niche Contributes to the More Aggressive Phenotype of LM8 Compared to Dunn Osteosarcoma Cells.
      Sarcoma 2013; 2013:404962 doi: 10.1155/2013/404962
    92. D.Meier, C.Campanile, S, Botter, W.Born, B.Fuchs. Cytotoxic Efficacy of Photodynamic Therapy in osteosarcoma Cells in vitro.
      J Vis Exp 2014 Mar 18; (85). Doi:10.3791/51213
    93. P.Brennecke, M.Arlt, K.Husmann, C.Campanile, A.Gvozdenovic, T.D’Apuzzo, M.Thelen, W.Born, B.Fuchs. CXCR4 Antibody Treatment Suppresses Metastatic Spread to the Lung of Intratibial Human Osteosarcoma Xenografts In Mice.
      Clin Exp Metastasis 31(3):339-49, 2014
    94. C.Pauli, B.Fuchs, C.Pfirrmann, JA.Bridge, S.Hofer, B.Bode: Response of an Aggressive Periosteal Aneurysmal Bone Cyst (ABC) of the Radius to Denosumab Therapy.
      World J Surg Oncol 12(1): 17, 2014  Doi: 10.1186/1477-7819-12-17 (IF 1.092)
    95. K.Modaressi, P.Giovanoli, P.Schneider, T.Sulser, C.Werner, B.Bode, B.Fuchs. Rezidivierendes Rektumkarzinom: Sakrektomie mit kompletter dorsaler Exenteration.
      Leading Opinions Orthopedics & Rheumatology 1/14:46-8, 2014
    96. S.Botter, D.Neri, B.Fuchs. Recent Advances in Osteosarcoma.
      Curr Opin Pharmacol 16C:15-23, 2014
    97. NR.Datta, E.Puric, R.Schneider, B.Fuchs, S.Bodis, D.Weber. HYPROSAR: Hyperthermia and Proton Radiotherapy in Soft Tissue Sarcoma.
      Leading Opinions Hämatologie & Onkologie 2:158-60, 2014
    98. M.Arlt, I.Banke, D.Walters, K.Berndt, E.Strehler, W.Born, B.Fuchs. The Use of LacZ-transduced Tumor Cells Enhances the Sensitivity of Micrometastasis Detection: A Comparative Study of Gemcitabine Treatment Efficacy in the Mouse LM8 Osteosarcoma Cell Model.
      J Cancer Res Ther 2(6):89-95, 2014
    99. T.Jentzsch, B.Robl, M.Husmann, B.Bode, B.Fuchs. Worse Prognosis of Osteosarcoma Patients expressing IGF-1 on a Tissue Microarray
      Anticancer Res 34(8):3881-9, 2014
    100. RMR. Kumar, MM.Betz, B.Robl, W.Born, B.Fuchs. ΔNp63alpha Exerts Its Oncogenic Potential via Transcriptionally Regulating GLI2 in Osteosarcoma Cells.
      BMC Cancer 14: 559, 2014
    101. M.Rimann, S.Laternser, A.Gvozdenovic, R.Muff, B.Fuchs, J.Kelm, U.Graf-Hausner. An In-vitro Osteosarcoma 3D Microtissue Model for Drug Development.
      J Biotechnology 189C:129-135, 2014
    102. T.Jentzsch, B.Robl, M.Husmann, B.Bode, B.Fuchs. Expression of MSH2 and MSH6 on a Tissue Microarray in Patients with Osteosarcoma.
      Anticancer Res 34(12):6961-72, 2014
    103. B.Fuchs. Research and Development in Tumour Surgery: The Importance of Team Work.
      Swiss Cancer Research Foundation 1:95-99, 2014
    104. R.Cathomas, C.Rothermundt, B.Bode, B.Fuchs, R.von Moos, M.Schwitter. RANK ligand Blockade with Denosumab in Combination with Sorafenib in Chemorefractory Osteosarcoma: a possible Step forward?
      Oncology 88(4):257-60, 2015
    105. K.Husmann, M.Arlt, P.Jirkof, M.Arras, W.Born, B.Fuchs. Primary Tumour Growth in an Orthotopic Osteosarcoma Mouse Model Is Not Inflenced By Analgesic Treatment with Buprenorphine And Meloxicam.
      Laboratory Animals 49(4):284-93, 2015
    106. B.Robl, C.Pauli, S.Botter, B.Bode, B.Fuchs. Prognostic Value of Tumor Suppressors in Osteosarcoma Before and After Neoadjuvant Chemotherapy.
      BMC Cancer 15(1):379- , 2015
    107. NR.Datta, R.Grobholz, E.Puric, B.Bode, N.Lomax, S.Khan, US. Gaipl, B.Fuchs, S.Bodis. Enhanced Tumour Regression in a Patient of Liposarcoma Treated with Radiotherapy and Hyperthermia: Hint for Dynamic Immunomodulation by Hperthermia.
      Int J Hyperthermia 20:1-4, 2015
    108. A.Boro, M.Arlt, H.Lengnick, B.Robl, M.Husmann, J.Bertz, W.Born, B.Fuchs. Prognostic Value and in-vitro Biological Relevance of Neuropilin 1 and Neuropilin 2 in Osteosarcoma.
      Am J Translational Res 7(3):640-53, 2015
    109. T.Jentzsch, B.Fuchs. Therapie von Sarkomen.
      InFo@Onkologie&Hämatologie 3(5):1-6, 2015
    110. G.Studer, M.Brown, B.Fuchs. Radiotherapie bei Weichteilsarkomen des Erwachsenen: Präoperative und Dosis-Volumen-konformierende Anwendung
      InFo@Onkologie 2:13-15, 2015
    111. S.Hodel, F.Seeli, B.Fuchs. Demographische Analyse von Patienten mit Osteosarkom, Chondrosarkom, Ewing’s Sarkom von einem Sarkomzentrum in der Schweiz.
      PRAXIS Schweizerische Rundschau für Medizin 104(13):673-80, 2015
    112. R.Muff, P.Rath, R.Kumar, K.Husmann, W.Born, M.Baudis, B.Fuchs. Genomic Instability of Osteosarcoma Cell Lines during Long-term in vitro Culture.
      PlosOne 10(5):e0125611, 2015
    113. R.Kumar, B.Fuchs. Hedgehog Signaling Inhibitors as Anti-cancer Agents in Osteosarcoma.
      Cancers  7(2):784-94, 2015
    114. R.Kumar, M.Arlt, B.Robl, A.Kuzmanov, O.Neklyudova, K.Husmann, W.Born, B.Fuchs. Sunitinib Malate (SU-11248) Reduces Intratibial Tumour Burden And Lung Metastasis In a Preclinical Mouse Model Of Osteosarcoma.
      Am J Cancer Res 5(7):2156-68, 2015
    115. K.Husmann, P.Ducommun, A.Sabile, E.Pedersen, W.Born, B.Fuchs. Signal Transduction and Downregulation of C-Met in HGF-stimulated Low and Highly Metastatic Human Osteosarcoma Cell Lines.
      Biochem Biophys Res Commun 464(4):1222-7, 2015
    116. B.Fuchs. Swiss National Sarcoma Advisory Board: Vorstellung des Schweizer Konsensus.
      Leading Opinions Hämatologie&Onkologie 3(15):78-80, 2015
    117. D.Müller, B.Fuchs. Whoops Läsionen bei Weichteilsarkomen.
      InFo@Onkologie&Hämatologie 8:26-29, 2015
    118. M.Ture, J.Barth, F.Angst, A.Aeschlimann, U.Schnyder, N.Zerkiebel, J.Perseus, C.Renner, P.Imesch, B.Fuchs, G.Huber, H.Walt, C.Martin-Soelch, J.Jenewein. Use of Inpatient Rehabilitation for Cancer patients in Switzerland: Who undergoes Cancer Rehabilitation?
      Swiss Medical Weekly December 4, 2015 DOI 10.4414/smw.2015.14214
    119. A.Boro, D.Bauer, W.Born, B.Fuchs. Plasma Levels of MIRNA-155 as a Powerful Diagnostic Marker for Dedifferentiated Liposarcoma.
      Am J Cancer Res 6(2):544-52, 2016
    120. R.Muff, S.Botter, K.Husmann, J.Tchinda, P.Selvam, F.Seeli-Maduz, B.Fuchs. Explant Culture of Sarcoma Patients’ Tissue.
      Lab Invest  DOI:10.1038 April 26, 2016
    121. O.Neklyudova, M.Arlt, P.Brennecke, M.Thelen, A.Gvozdenovic, A.Kuzmanov, B.Robl, S.Botter, W.Born, B.Fuchs. Altered CXCL12 Expression Reveals a Dual Role of CXCR4 in Osteosarcoma Primary Tumor Growth and Metastasis.
      J Cancer Res Clin Oncol Epub ahead of print June 14 2016
    122. Daniel Burger, M.Pumberger, B.Fuchs. An Uncemented Spreading Stem for the Fixation in the Metaphyseal Femur: A Preliminary Report
      Sarcoma May 15, 2016:7132838. Doi:10.1155/2016/7132838
    123. R.Kumar, A.Boro, B.Fuchs. Involvement and Clinical Apsects of microRNA in Osteosarcoma: A Review.
      Int J Mol Sci 2016 Jun 3:17(6)
    124. A. Gvozdenovic, A.Boro, D.Meier, B.Bode-Lesniewska, W.Born, R.Muff, B.Fuchs. Targeting αvβ3 and αvβ5 Integrins Inhibits Pulmonary Metastasis in an Intratibial Xenograft Osteosarcoma Model.
      Oncotarget accepted June 17, 2016
    125. B.Robl, S.Botter, G.Pellegrini, O.Neklyudova, B.Fuchs. Evaluation of Intraarterial and Intravenous Cisplatin Chemotherapy in the Treatment of Metastatic Osteosarcoma using an Orthotopic Xenograft Mouse Model.
      J Exp Clin Cancer Res 35(1):113, 2016
    126. T.Jentzsch, L.Vlachopoulos, P.Fürnstahl, D.Müller, B.Fuchs. Tumor Resection at the Pelvis using Three-dimensional Planning and Patient-specific Instruments: A Case Series.
      World Journal of Surg Oncology accepted Sept 12, 2016
    127. M.Scaglioni, N.Lindenblatt, A.Barth, B.Fuchs, W.Weder, P.Giovanoli. Free Fillet Flap Application to Cover Forequarter or Traumatic Aputation on an Upper Extremity: A Case Report.
      Microsurgery Oct 20, 2016 doi:10.1002/micr.30124.
    128. A.Arteau, B.Fuchs. Complete Deltoid Resection in Infancy results in Normal Shoulder Function at Longterm Followup.
      J Medical Case Reports in print Oct 28, 2016
    129. D.Meier, S.Botter, C.Campanile, B.Robl, S.Gräfe, G.Pellegrini, W.Born, B.Fuchs. Foscan and Foslip based Photodynamic Therapy in Osteosarcoma in vitro and in Intratibial Mouse Models.
      International J Cancer Dec 10, 2016 Epub ahead of print