Neurochirurgie

Dr. med. Mattia Bellinzona

Oberarzt Klinik für Neurochirurgie
Facharzt für Neurochirurgie

Ausbildung und Klinische Tätigkeiten
01/1992–12/1994Post doktoral fellow Brain Tumor Research Center UCSF San Francisco/USA-Abteilung des Prof. J.R. Fike
01/1995Krankenhaus Nordstadt Hannover/Deutschland Neurochirurgische Abteilung Assistenzarzt
12/2001Facharzt für Neurochirurgie FMH
06/2004Funktionsoberarzt für Neurochirurgie
01/2007Oberarzt für Neurochirurgie/ NCH Abteilung Krankenhaus „Brotzu“, Cagliari (Italien)
04/2012Oberarzt für Neurochirurgie KSW
Besondere Qualifikationen
Fachkunde im Strahlenschutz für Röntgendiagnostik (Ärztekammer Niedersachsen)
United States Medical License Examination Step I and II ECFMG Certifikat

Veröffentlichungen
Aste L, Bellinzona M, Meleddu V, Farci G, Manieli C and Godano U,
Xanthomatous hypophysitis mimicking a pituitary adenoma: case report and review of the literature
J Oncol. 2010;2010:195323. Epub 2010 Jul 8

Godano U, Raffaela F, Meleddu V, M.D., and Bellinzona M.
Hemorrhagic colloid cyst with sudden coma. Case Illustration
Minimally Invasive Neurosurgery, accepted for publication, 2010

Sigari A.,Bellinzona M., Becker H. and Samii M.
Epidermoid cyst of the cerebellopontine angle with extension into the middle and anterior cranial fossae: surgical strategy and review of the literature.
Acta Neurochir (Wien). 2007; 149 (4): 429-32

Roser F., Nakamura M., Ritz R., Bellinzona M., Rietz R., Ostertag H. and Tatagiba MS.
Proliferation potential of spinal meningiomas.
Eur Spine J. 2006 Feb; 15(2):211-5

Roser F., Nakamura M., Ritz R., Bellinzona M., Dietz K., Samii M. and Tatagiba MS.
Proliferation and progesterone receptor status in benign meningiomas are not age dependent.
Cancer 2005 Aug 1;104(3):598-601

M. Bellinzona a, F. Roser a,b, H. Ostertag c, R.M. Gaab a, M. Saini d.
Surgical removal of Primary Central Nervous System Lymphomas (PCNSL) presenting as space occupying lesions: a series of 33 cases.
Eur. J. Surg. Oncology, 2005

Roser F., Nakamura M., Bellinzona M., Rosahl SK., Ostertag H. and Samii M.
The prognostic value of progesterone receptor status in meningiomas.
J Clin Pathol. 2004 Oct;57(10):1033-7.

Saini, M., Roser, F., Hussein, S., Samii, M. and Bellinzona, M.
Intralesional mitoxantrone biopolymer-mediated chemotherapy prolongs survival in rats with experimental brain tumors.
J Neurooncol. 2004 Jul;68(3):225-32.

Bellinzona M., Roser F., Matthies C., Samii M. and Saini M.

Biopolymer-mediated suramin chemotherapy in the treatment of experimental brain tumours.

Acta Oncol. 2004;43(3):259-63.

Roser F., Samii, M., Ostertag H. and Bellinzona M.

The Proliferation antigen Ki-67 in Meningiomas. Experience in 600 cases.

Acta Acta Neurochir (Wien). 2004 Jan;146(1):37-44.

Saini, M., Roser F., Samii M. and Bellinzona M.

A model for intratumoral chemotherapy in the rat brain.

Acta Neurochir (Wien). 2004 Jul;146(7):731-4.

Roser, F., Saini, M., Meliss, R., Ostertag, H., Samii M. and Bellinzona, M.

Apoptosis, vascularity and proliferation in Primary Central Nervous System Lymphomas (PCNSL): A histopathological study.

Surgical Neurology 2004 Nov; 62(5):393-399

Saini M, Bellinzona M, Meyer F, Cali G, Samii M.

Morphometrical characterization of two glioma models in the brain of immunocompetent and immunodeficient rats.

J Neuro-Oncology 42: 59-67, 1999.

Saini M, Bellinzona M, Weichhold W, Samii M.

A new xenograft model of primary central nervous system lymphoma.

J Neuro-Oncology 43: 153-160, 1999.

Saini M, Bellinzona M, Hinojosa M, Samii M, Weichhold W, Ostertag H

Primary CNS lymphoma: a clinical study.

Zentralblatt Neurochirurgie 50(suppl) 93, 1999.

Saini M, Bellinzona M, Gunther T, De la Riva R, Samii M.

In vitro and in vivo long-lasting release of thyrpostine for chemotherapy of brain tumors.

Zentralblatt Neurochirurgie 49(suppl) 112, 1998.

Gobbel GT, Bellinzona M, Vogt AR, Gupta N, Fike JR and Chan PH.

Response of post-mitotic neurons to x-irradiation: implications for the role of DNA damage in neuronal apoptosis.

J. of Neurosciences, 18(1):147-55, 1998.

Zink PM, Samii M, Luedemann W, Bellinzona M and Prokop M.

Accuracy of single-energy quantitative computed tomography in the assessment of bone mineral density of cervical vertebrae.

European Radiology 7, 1436-1440, 1997.

Saini M, Bellinzona M, Meyer F, Samii M.

The importance of vasculogenesis in the therapy of glioma of CNS. Zentralblatt Neurochirurgie 49 (suppl) 71, 1997. Stancic MF, Eskinja M, Bellinzona M, Micovic V, Stosic A and Tomljanovic Z. The role of interfascicular nerve grafting after gunshot wounds: a report of 44 cases.

International Orthopaedics, 20:87-91, 1996.

Bellinzona M, Gobbel GT , Shinohara C and Fike JR.

Apoptosis is induced in the subependyma of young adult rats by ionizing irradiation.

Neurosciences Letters, 208: 163-166, 1996.

Nakagawa M, Bellinzona M, Seilhan T, Gobbel GT, Lamborn K and Fike JR.

Microglial responses after focal radiation-induced injury are affected by alpha-difluormethylornithine.

Int. J. Rad. Onc. Biol. Phys., Vol. 36, No 1, pp. 113-123, 1996.

Fike JR, Gobbel GT, Chou G, Wijnhoven B, Bellinzona M, Nakagawa M, and Seilhan T.

Cellular proliferation and infiltration following interstitial irradiation of normal dog brain is altered by an inhibitor of polyamine synthesis.

Int. J. Radiation Oncology Biol. Phys., Vol. 32, No. 4, pp. 1035-1045, 1995.

Sotgiu ML and Bellinzona M.

Effects of lateral reticular nucleus stimulation on trigeminal sensory and motor neuron activity related to the jaw opening reflex.

Pain 46, 67-74,1991.

Abtracts
Roser F., Saini, M., Matthies C. and Bellinzona M.

Controlled release of mitoxantrone from Ethylene-vinyl acetate copolymer for intracerebral drug delivery.

55. Jahrestagung für Neurochirurgie, Köln, 2004

Roser F, Saini M, Meliss R, Brandis A, Ostertag H, Samii M and Bellinzona M

Apoptosis, vascularity and proliferation in Primary central nervous system lymphomas (PCNSL): a clinical and histopathological study.

52. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie, Halle, 2001

Bellinzona M, Saini M, Penco M, Ferruti P, Samii M

Tossicità in vivo di due nuovi biopolimeri nel cervello di ratto.

XLIX Congresso Nazionale della Società Italiana di Neurochirurgia. p 428, 2000

Saini M, Bellinzona M, Guenther T, De La Riva R and Samii M

In vitro and in vivo long-lasting release of thyrpostine for chemotherapy of brain tumors

49. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie, Hannover, 12-16 Juni 1998

Saini M, Bellinzona M, Weichhold W, Hinojosa M, Tatagiba M, Penkert G, and Samii M Primary

CNS lymphoma: a clinical study

3rd Congress of the European Association for Neuro-Oncology, Versailles, September 13-16, 1998

Saini M, Weichhold W, Hinojosa M, Bellinzona M, Penkert G, Samii M

Linfomi primitivi del Sistema Nervoso Centrale: studio clinico e immunoistologico.

XLVII Congresso Nazionale della Società Italiana di Neurochirurgia. p 41, 1998

Saini M, Bellinzona M, Weichhold W, Hinojosa M, Tatagiba M, Penkert G, Samii M

A clinico-pathological study on 27 primary CNS lymphomas.

Eurocancer, p 182, 1998

Bellinzona M, Saini M, Samii M, Gobbel GT, Vogt R, Fike JR, Chan PH
Apoptosis is induced by X-irradiation in post-mitotic neurons but not in astrocytes.

Eurocancer, 183, 1998

Bellinzona M, Saini M, Samii M, Gobbel GT, Vogt R, Fike JR, Chan PH

L´esposizione ai raggi X induce apoptosi nei neuroni post-mitotici.

XLVII. Congresso Nazionale della Società Italiana di Neurochirurgia. p 67, 1998

Saini M, Bellinzona M, Penco M, Ferruti P, Meyer F, Samii M

A new biodegradable polymer for direct intracerebral chemotherapy.

49th Congress of Skull Base Surgery, 1997

Saini M, Bellinzona M, Samii M

Intratumoral antivascular therapy in experimental gliomas.

Eurocancer p 397, 1997.

Saini M, Bellinzona M, Samii M

Biopolymer-mediate long lasting release of suramin for interstitial glioma therapy: preliminary results.

Eurocancer, p 408,1997

Bellinzona M, Gobbel GT, Shinohara C and Fike JR

Apoptosis is induced in the subependyma of young adult rats by ionizing radiation

11th International Congress of Neurosurgery, 1997 Amsterdam

Saini M, Bellinzona M, Penco M, Ferruti P, Meyer F, Samii M

A new biodegradable polymer for direct intracerebral chemotherapy

49th Congress of Skull Base Surgery, Berlin 1997.

Shinohara C, Bellinzona M, Gobbel G and Fike JR

Cdc2 expression and apoptosis in normal rat brain after x-irradiation

11th Int. Conference on Brain Tumor Research and Therapy, Silverado- Napa, California, Oct. 31- Nov. 3, 1995

Fike JR, Nakagawa M, Bellinzona M, Gobbel GT, Wijnhoven BPL and Chou D Cell responses in irradiated normal brain are altered by DFMO. 10th Int. Congress of Radiation Research, Würzburg, Germany

Fike JR, Nakagawa M, Bellinzona M, Gobbel GT, Wijnhoven BPL and Chou D

Cell responses in irradiated normal brain are altered by DFMO.

11th Int. Conference on Brain Tumor Research and Therapy, Silverado- Napa, California, Oct. 31- Nov. 3, 1995 (data partially presented in Würzburg, Germany, for the 10th Int. Congress of Radiation Research)

Gobbel GT, Bellinzona M, Vogt AR, Fike JR and Chan PH

Radiation induces apoptosis in post-mitotic neurons

11th Int. Conference on Brain Tumor Research and Therapy, Silverado- Napa, California, Oct. 31- Nov. 3, 1995

Fike JR, Gobbel GT, Chou D, Wijnhoven BPL, Bellinzona M and Nakagawa M

Radiation-induced brain injury is reduced by polyamine inhibitor DFMO.

UCSF, San Francisco, CA 94143.

Bellinzona M, Ross G, Gobbel GT and Fike JR

Radiation-induced DNA damage in young and aged rat brain.

UCSF, San Francisco, CA 94143. Radiation Research Society-42nd Annual Meeting, Nashville, 1994

Bellinzona M, Hu S, Ross G, Gobbel GT, Chen C-Z, Deen, DF and Fike JR

An in vivo model of DNA double strand breaks induction and repair after x-irradiation.

UCSF, San Francisco, CA 94143. Radiation Research Society – 41st Annual Meeting, Dallas, 1993

Fike JR, Chou D, Wijnhoven BPL, Gobbel GT and Bellinzona M

Cellular response after interstitial brain irradiation.

UCSF, San Francisco, CA 94143

Gobbel GT, Bellinzona M, Fike JR and Chan PH

Response of normal rat astrocytes and cerebral endothelial cells to radiation.

UCSF, San Francisco, CA 94143

Sotgiu ML and Bellinzona M

Influence from the lateral reticular nucleus and the nucleus gigantocellularis on the periacqueductal gray.

Abstracts of the 12th Annual Meeting of the European Neurosciences Association, Turin (Italien), 1989

Vorträge
Bellinzona M., Roser F., Matthies C., Samii M. and Saini, M.

Biopolymer-mediated suramin chemotherapy in the treatment of experimental brain tumours.

55. Jahrestagung für Neurochirurgie, Köln, 2004

Bellinzona M., Roser F., Saini, M. and Samii M.

A model for intratumoral chemotherapy in the rat brain.

55. Jahrestagung für Neurochirurgie, Köln, 2004

Bellinzona, M, Saini, M, Matthies C, Samii-Hussein, Samii M.

Intralesional mitoxantrone biopolymer-mediated chemotherapy prolongs survival in rats with experimental brain tumors.

Kongress der DGNC, Bielefeld 2001

Bellinzona M, Saini M, Weichhold W, Samii M.

Un nuovo modello di linfoma primitivo del sistema nervoso centrale nel ratto.

XLIX Congresso Nazionale della Società Italiana di Neurochirurgia. p 57, 2000

Saini M, Bellinzona M, Weichhold W, Samii M.

La terapia biopolimero-mediata con EVAc-mitoxantrone prolunga la sopravvivenza in un modello animale di glioma.

XLIX Congresso Nazionale della Società Italiana di Neurochirurgia. p 57, 2000

Bellinzona M, Saini M, Samii M, Gobbel GT, Vogt R, Fike JR, Chan PH

L’esposizione ai raggi X induce apoptosi nei neuroni post-mitotici,

Congresso della Societá Italiana di Neurochirurgia, Trieste, 1998

Bellinzona M, Saini M, Samii M, Gobbel GT, Vogt R, Fike JR, Chan PH

Apoptosis is induced by radiation in post-mitotic neurons

3rd Congress of the European Association for Neuro-Oncology, Versailles, September 13-16, 1998

Bellinzona M, Gobbel GT, Shinohara C and Fike JR

Time and regional distribution of radiation-induced apoptosis in the adult rat brain.

Eurocancer, Paris, June 1997

Saini M, Bellinzona M and Samii M

Intratumoral antivascular therapy in experimental gliomas.

Eurocancer, Paris, June 1997

Bellinzona M

Radiation-induced DNA double strand breaks in the rat brain: in vivo and in vitro studies.

Upon invitation from Prof. N. de Tribolet, MD, Head and Chairman of the Dept. Of Neurosurgery, CHUV, Lausanne, Switzerland, 1994