Anästhesiologie

PD Dr. med. Philipp Stein
Stv. Leitender Arzt
Institut für Anästhesiologie
Koordinator Rega Basis Mollis
Facharzt für Anästhesiologie
Notarzt SGNOR DESA
Tätigkeit als Facharzt
seit 04/2019
Stv. Leitender Arzt
Institut für Anästhesiologie
Kantonsspital Winterthur
2014 – 2019
Oberarzt
Anästhesiologie
Universitätsspital Zürich
Facharzt- und Fähigkeitsausweise
2013
Facharzt für Anästhesiologie
2013
Fähigkeitsausweis Notarzt
Schweizerische Gesellschaft für Notfall und Rettungsmedizin (SGNOR)
2013
Europäisches Diplom, DESA
Weiterbildung zum Facharzt
2013
Anästhesiologie (Herzanästhesie)
Universitätsspital Zürich
2012 – 2013
Innere Medizin und Rega 12
Kantonsspital Glarus
2011
Intensivmedizin (Medizinisch), Anästhesiologie und Rega 1
Universitätsspital Zürich
2009-2010
Anästhesiologie
Universitätsspital Zürich
2009
Intensivmedizin (Herzchirurgisch)
Universitätsspital Zürich
2008
Anästhesiologie
Universitätsspital Zürich
Medizinische und akademische Laufbahn
2018
Habilitation (Venia legendi)
Universität Zürich
2010
Amerikanisches Staatsexamen (ECFMG)
2007
Dissertation und Promotion
Universität Freiburg im Breisgau
2007
Staatsexamen
Universität Freiburg im Breisgau
Zusatzqualifikationen und Aktivitäten
seit 2018
Gastgeber («Host»)
«European Diploma in Anaesthesiology and Intensive Care examination» in Zürich
seit 2018
Lehrbeauftragter
Medizinische Fakultät
Universität Zürich
2013
Instruktor
AHA ACLS und ERC ALS
2013
CEFOCA/SFG, Zertifikat Leitender Notarzt
2012
«Diploma of Moutain Medicine»
Schweizerische Gesellschaft für Anästhesiologie und Reanimation (SGAR)
Ressort Qualitätsmanagement
2010
Good Clinical Practice (GCP) Module 1-3
Universität Zürich
Spezialinteressen
- Präklinische Notfallmedizin
- Gerinnungsmanagement bei Trauma Patienten
- Transfusionsmedizin
- Patient Blood Management
Mitgliedschaften
- Schweizerische Ärztegesellschaft (FMH)
- Schweizerische Gesellschaft für Anästhesiologie und Reanimation (SGAR)
- Schweizerische Gesellschaft für Notfall- und Rettungsmedizin (SGNOR)
- European Society of Anaesthesiologists (ESA)
Originalarbeiten
- Repression of T-cell function by thionamides is mediated by inhibition of the activator protein-1/nuclear factor of activated T-cells pathway and is associated with a common structure.
Humar M, Dohrmann H, Stein P, Andriopoulos N, Goebel U, Heimrich B, Roesslein M, Schmidt R, Schwer C I, Hoetzel A, Loop T, Pahl H L, Geiger K K, Pannen B H J (2007)
Mol Pharmacol 72: 1647–1656
Impact factor: 3.922 (2017) - Thionamides inhibit the transcription factor nuclear factor-kappaB by suppression of Rac1 and inhibitor of kappaB kinase alpha.
Humar M, Dohrmann H, Stein P, Andriopoulos N, Goebel U, Roesslein M, Schmidt R, Schwer C I, Loop T, Geiger K K, Pahl H L, Pannen B H J (2008)
J Pharmacol Exp Ther. 324: 1037–1044, Impact factor: 3.867 (2017) - Carbon monoxide inhalation reduces pulmonary inflammatory response during cardiopulmonary bypass in pigs.
Goebel U, Siepe M, Mecklenburg A, Stein P, Roesslein M, Schwer C I, Schmidt R, Doenst T, Geiger K K, Pahl H L, Schlensak C, Loop T (2008)
Anesthesiology. 108: 1025–1036, Impact factor: 5.785 (2017) - Pulsatile Pulmonary Perfusion During Cardiopulmonary Bypass Reduces the Pulmonary Inflammatory Response.
Siepe M, Goebel U, Mecklenburg A, Doenst T, Benk C, Stein P, Beyersdorf F, Loop T, Schlensak C (2008).
Ann Thorac Surg. 86: 115–122, Impact factor: 3.700 (2017) - Up-regulation of heme oxygenase-1 by sevoflurane is not dependent on Kupffer cells and associates with ERK1/2 and AP-1 activation in the rat liver.
Schwer C I, Stoll P, Pietsch U, Stein P, Laqua J, Goebel U, Hoetzel A, Schmidt R (2010)
Int J Biochem Cell Biol. 42: 1876–1883, Impact factor: 3.505 (2017) - Ease and difficulty of pre-hospital airway management in 425 paediatric patients treated by a helicopter emergency medical service: a retrospective analysis.
Schmidt A R, Ulrich L, Seifert B, Albrecht R, Spahn D R, Stein P (2016)
Scand J Trauma Resusc Emerg Med. 24: 22, Impact factor: 2.036 (2017) - Failure rate of prehospital chest decompression after severe thoracic trauma.
Kaserer A*, Stein P*, Simmen H P, Spahn D R, Neuhaus V (2017)
Am J Emerg Med. 35: 469–474, Impact factor: 1.494 (2017) - Factors Influencing Quality of Pain Management in a Physician Staffed Helicopter Emergency Medical Service.
Oberholzer N, Kaserer A, Albrecht R, Seifert B, Tissi M, Spahn D R, Maurer K., Stein P (2017)
Anesth Analg. 125: 200–209, Impact factor: 4.014 (2017) - A smartphone application to determine body length for body weight estimation in children: a prospective clinical trial.
Wetzel O, Schmidt A R, Seiler M, Scaramuzza D, Seifert B, Spahn D R, Stein P (2017)
J Clin Monit Comput. 68: 441–451, Impact factor: 2.178 (2017) - Impact of city police layperson education and equipment with automatic external defibrillators on patient outcome after out of hospital cardiac arrest.
Stein P*, Spahn G H*, Müller S, Zollinger A, Baulig W, Brüesch M, Seifert B, Spahn D R (2017)
Resuscitation. 118: 27–34, Impact factor: 5.230 (2017) - Change of transfusion and treatment paradigm in major trauma patients.
Stein P, Kaserer A, Sprengel K, Wanner G A, Seifert B, Theusinger O M, Spahn D R (2017)
Anaesthesia. 72: 1317–1326, Impact factor 4.741 (2017) - Specialist advice may improve patient selection for decompression therapy following diving accidents: a retrospective observational study.
Steffensmeier D, Albrecht R, Wendling J, Melliger R, Spahn D R, Stein P, Wyss C (2017)
Scand J Trauma Resusc Emerg Med. 25: 101, Impact factor: 2.036 (2017) - The impact of prehospital tranexamic acid on blood coagulation in trauma patients.
Stein P*, Studt J D*, Albrecht R, Müller S, von OW D, Fischer S, Seifert B, Mariotti S, Spahn D R, Theusinger O M (2018)
Anesth Analg. 126: 522–529, Impact factor: 4.014 (2017) - Optimisation of the dosage of tranexamic acid in trauma patients with population pharmacokinetic analysis.
Grassin-Delyle S, Theusinger O M, Albrecht R, Müller S, Spahn D R, Urien S, Stein P (2017)
Anaesthesia. 73: 719-729, Impact factor: 4.741 (2017) - Comparison of two different coagulation algorithms on the use of allogeneic blood products and coagulation factors in severely injured trauma patients.
Kaserer A, Casutt M, Sprengel K, Seifert B, Spahn D R, Stein P (2018)
Scand J Trauma Resusc Emerg Med. 26: 4, Impact factor: 2.036 (2018) - Risk Factors for Higher-than-Expected Residual Rivaroxaban Plasma Concentrations in Real-Life Patients.
Kaserer A, Schedler A, Jetter A, Seifert B, Spahn D R, Stein P, Studt J D (2018)
Thromb Hemost. 118: 808-817, Impact factor: 5.6
Fallberichte
- Dabigatran anticoagulation and Stanford type A aortic dissection: lethal coincidence: Case report with literature review.
Stein P, Bosshart M, Brand B, Schlicker A, Spahn D R, Bettex D (2014)
Acta Anaesthesiol Scand. 58: 630–637, Impact factor: 2.438 (2017) - Multiple trauma, resuscitation, and 15 minutes of esophageal intubation: survival without neurologic deficit.
Stein P, Albrecht R, Spahn D R (2014)
Am J Emerg Med. 32: 950.e1–2, Impact factor: 1.494 (2017) - Schwieriger präklinischer Atemweg und Bergung an der Rettungswinde.
Stein P, Meyer J, Mariotti S, Spahn D R, Albrecht R (2015)
Notarzt. 31: 129–133, Impact factor: 0.318 (2017) - Massive coagulopathy caused by the bite of a Crotalus basiliscus snake.
Meyer S, Hartmann F, Stein P, Lenherr R, Fuchs J, Spahn D R (2017)
Anaesth Cases. Epub.
Übersichtsarbeiten
- Applying “Patient Blood Management” in the trauma center.
Theusinger O M, Stein P, Spahn D R (2014)
Curr Opin Anaesthesiol. 27: 225–232, Impact factor: IF 2.369 (2017) - Transfusion strategy in multiple trauma patients.
Theusinger O M, Stein P, Spahn D R (2014)
Curr Opin Crit Care. 20: 646–655, Impact factor: 3.316 (2017) - Evidence base for restrictive transfusion triggers in high-risk patients.
Spahn D R, Spahn G H, Stein P (2015)
Transfus Med Hemother. 42: 110–114, Impact factor: 1.76 (2017) - Point of Care and Factor Concentrate-Based Coagulation Algorithms.
Theusinger O M, Stein P, Levy J H (2015)
Transfus Med Hemother. 42: 1–7, Impact factor: 1.76 (2017) - Indications and Risks of Fibrinogen in Surgery and Trauma.
Spahn D R, Spahn G H, Stein P (2015)
Semin Thromb Hemost. 42: 147–154, Impact factor: 3.629 (2017) - Point-of-Care Coagulation Monitoring in Trauma Patients.
Stein P, Kaserer A, Spahn G H, Spahn D R (2017)
Semin Thromb Hemost. 43: 367–374, Impact factor: 3.629 (2017) - „Patient blood management“ ist heute Standard.
Spahn D R, Kaserer A, Spahn G H, Stein P (2017)
Schweiz Med Forum. 17: 1145-1147, Impact factor: 2.068 (2017) - Patient Blood Management: Der Standard heute
Kaserer A, Stein P, Spahn G H, Spahn D R (2017)
Ther Umsch. 74: 369-376, Impact factor: 0.18 (2017)
-
Curriculum vitae
Tätigkeit als Facharzt
seit 04/2019
Stv. Leitender Arzt
Institut für Anästhesiologie
Kantonsspital Winterthur2014 – 2019
Oberarzt
Anästhesiologie
Universitätsspital Zürich
Facharzt- und Fähigkeitsausweise
2013
Facharzt für Anästhesiologie2013
Fähigkeitsausweis Notarzt
Schweizerische Gesellschaft für Notfall und Rettungsmedizin (SGNOR)2013
Europäisches Diplom, DESA
Weiterbildung zum Facharzt
2013
Anästhesiologie (Herzanästhesie)
Universitätsspital Zürich2012 – 2013
Innere Medizin und Rega 12
Kantonsspital Glarus2011
Intensivmedizin (Medizinisch), Anästhesiologie und Rega 1
Universitätsspital Zürich2009-2010
Anästhesiologie
Universitätsspital Zürich2009
Intensivmedizin (Herzchirurgisch)
Universitätsspital Zürich2008
Anästhesiologie
Universitätsspital Zürich
Medizinische und akademische Laufbahn
2018
Habilitation (Venia legendi)
Universität Zürich2010
Amerikanisches Staatsexamen (ECFMG)2007
Dissertation und Promotion
Universität Freiburg im Breisgau2007
Staatsexamen
Universität Freiburg im Breisgau
Zusatzqualifikationen und Aktivitäten
seit 2018
Gastgeber («Host»)
«European Diploma in Anaesthesiology and Intensive Care examination» in Zürichseit 2018
Lehrbeauftragter
Medizinische Fakultät
Universität Zürich2013
Instruktor
AHA ACLS und ERC ALS2013
CEFOCA/SFG, Zertifikat Leitender Notarzt2012
«Diploma of Moutain Medicine»
Schweizerische Gesellschaft für Anästhesiologie und Reanimation (SGAR)
Ressort Qualitätsmanagement2010
Good Clinical Practice (GCP) Module 1-3
Universität Zürich
Spezialinteressen
- Präklinische Notfallmedizin
- Gerinnungsmanagement bei Trauma Patienten
- Transfusionsmedizin
- Patient Blood Management
Mitgliedschaften
- Schweizerische Ärztegesellschaft (FMH)
- Schweizerische Gesellschaft für Anästhesiologie und Reanimation (SGAR)
- Schweizerische Gesellschaft für Notfall- und Rettungsmedizin (SGNOR)
- European Society of Anaesthesiologists (ESA)
-
Publikationen
Originalarbeiten
- Repression of T-cell function by thionamides is mediated by inhibition of the activator protein-1/nuclear factor of activated T-cells pathway and is associated with a common structure.
Humar M, Dohrmann H, Stein P, Andriopoulos N, Goebel U, Heimrich B, Roesslein M, Schmidt R, Schwer C I, Hoetzel A, Loop T, Pahl H L, Geiger K K, Pannen B H J (2007)
Mol Pharmacol 72: 1647–1656
Impact factor: 3.922 (2017) - Thionamides inhibit the transcription factor nuclear factor-kappaB by suppression of Rac1 and inhibitor of kappaB kinase alpha.
Humar M, Dohrmann H, Stein P, Andriopoulos N, Goebel U, Roesslein M, Schmidt R, Schwer C I, Loop T, Geiger K K, Pahl H L, Pannen B H J (2008)
J Pharmacol Exp Ther. 324: 1037–1044, Impact factor: 3.867 (2017) - Carbon monoxide inhalation reduces pulmonary inflammatory response during cardiopulmonary bypass in pigs.
Goebel U, Siepe M, Mecklenburg A, Stein P, Roesslein M, Schwer C I, Schmidt R, Doenst T, Geiger K K, Pahl H L, Schlensak C, Loop T (2008)
Anesthesiology. 108: 1025–1036, Impact factor: 5.785 (2017) - Pulsatile Pulmonary Perfusion During Cardiopulmonary Bypass Reduces the Pulmonary Inflammatory Response.
Siepe M, Goebel U, Mecklenburg A, Doenst T, Benk C, Stein P, Beyersdorf F, Loop T, Schlensak C (2008).
Ann Thorac Surg. 86: 115–122, Impact factor: 3.700 (2017) - Up-regulation of heme oxygenase-1 by sevoflurane is not dependent on Kupffer cells and associates with ERK1/2 and AP-1 activation in the rat liver.
Schwer C I, Stoll P, Pietsch U, Stein P, Laqua J, Goebel U, Hoetzel A, Schmidt R (2010)
Int J Biochem Cell Biol. 42: 1876–1883, Impact factor: 3.505 (2017) - Ease and difficulty of pre-hospital airway management in 425 paediatric patients treated by a helicopter emergency medical service: a retrospective analysis.
Schmidt A R, Ulrich L, Seifert B, Albrecht R, Spahn D R, Stein P (2016)
Scand J Trauma Resusc Emerg Med. 24: 22, Impact factor: 2.036 (2017) - Failure rate of prehospital chest decompression after severe thoracic trauma.
Kaserer A*, Stein P*, Simmen H P, Spahn D R, Neuhaus V (2017)
Am J Emerg Med. 35: 469–474, Impact factor: 1.494 (2017) - Factors Influencing Quality of Pain Management in a Physician Staffed Helicopter Emergency Medical Service.
Oberholzer N, Kaserer A, Albrecht R, Seifert B, Tissi M, Spahn D R, Maurer K., Stein P (2017)
Anesth Analg. 125: 200–209, Impact factor: 4.014 (2017) - A smartphone application to determine body length for body weight estimation in children: a prospective clinical trial.
Wetzel O, Schmidt A R, Seiler M, Scaramuzza D, Seifert B, Spahn D R, Stein P (2017)
J Clin Monit Comput. 68: 441–451, Impact factor: 2.178 (2017) - Impact of city police layperson education and equipment with automatic external defibrillators on patient outcome after out of hospital cardiac arrest.
Stein P*, Spahn G H*, Müller S, Zollinger A, Baulig W, Brüesch M, Seifert B, Spahn D R (2017)
Resuscitation. 118: 27–34, Impact factor: 5.230 (2017) - Change of transfusion and treatment paradigm in major trauma patients.
Stein P, Kaserer A, Sprengel K, Wanner G A, Seifert B, Theusinger O M, Spahn D R (2017)
Anaesthesia. 72: 1317–1326, Impact factor 4.741 (2017) - Specialist advice may improve patient selection for decompression therapy following diving accidents: a retrospective observational study.
Steffensmeier D, Albrecht R, Wendling J, Melliger R, Spahn D R, Stein P, Wyss C (2017)
Scand J Trauma Resusc Emerg Med. 25: 101, Impact factor: 2.036 (2017) - The impact of prehospital tranexamic acid on blood coagulation in trauma patients.
Stein P*, Studt J D*, Albrecht R, Müller S, von OW D, Fischer S, Seifert B, Mariotti S, Spahn D R, Theusinger O M (2018)
Anesth Analg. 126: 522–529, Impact factor: 4.014 (2017) - Optimisation of the dosage of tranexamic acid in trauma patients with population pharmacokinetic analysis.
Grassin-Delyle S, Theusinger O M, Albrecht R, Müller S, Spahn D R, Urien S, Stein P (2017)
Anaesthesia. 73: 719-729, Impact factor: 4.741 (2017) - Comparison of two different coagulation algorithms on the use of allogeneic blood products and coagulation factors in severely injured trauma patients.
Kaserer A, Casutt M, Sprengel K, Seifert B, Spahn D R, Stein P (2018)
Scand J Trauma Resusc Emerg Med. 26: 4, Impact factor: 2.036 (2018) - Risk Factors for Higher-than-Expected Residual Rivaroxaban Plasma Concentrations in Real-Life Patients.
Kaserer A, Schedler A, Jetter A, Seifert B, Spahn D R, Stein P, Studt J D (2018)
Thromb Hemost. 118: 808-817, Impact factor: 5.6
Fallberichte
- Dabigatran anticoagulation and Stanford type A aortic dissection: lethal coincidence: Case report with literature review.
Stein P, Bosshart M, Brand B, Schlicker A, Spahn D R, Bettex D (2014)
Acta Anaesthesiol Scand. 58: 630–637, Impact factor: 2.438 (2017) - Multiple trauma, resuscitation, and 15 minutes of esophageal intubation: survival without neurologic deficit.
Stein P, Albrecht R, Spahn D R (2014)
Am J Emerg Med. 32: 950.e1–2, Impact factor: 1.494 (2017) - Schwieriger präklinischer Atemweg und Bergung an der Rettungswinde.
Stein P, Meyer J, Mariotti S, Spahn D R, Albrecht R (2015)
Notarzt. 31: 129–133, Impact factor: 0.318 (2017) - Massive coagulopathy caused by the bite of a Crotalus basiliscus snake.
Meyer S, Hartmann F, Stein P, Lenherr R, Fuchs J, Spahn D R (2017)
Anaesth Cases. Epub.
Übersichtsarbeiten
- Applying “Patient Blood Management” in the trauma center.
Theusinger O M, Stein P, Spahn D R (2014)
Curr Opin Anaesthesiol. 27: 225–232, Impact factor: IF 2.369 (2017) - Transfusion strategy in multiple trauma patients.
Theusinger O M, Stein P, Spahn D R (2014)
Curr Opin Crit Care. 20: 646–655, Impact factor: 3.316 (2017) - Evidence base for restrictive transfusion triggers in high-risk patients.
Spahn D R, Spahn G H, Stein P (2015)
Transfus Med Hemother. 42: 110–114, Impact factor: 1.76 (2017) - Point of Care and Factor Concentrate-Based Coagulation Algorithms.
Theusinger O M, Stein P, Levy J H (2015)
Transfus Med Hemother. 42: 1–7, Impact factor: 1.76 (2017) - Indications and Risks of Fibrinogen in Surgery and Trauma.
Spahn D R, Spahn G H, Stein P (2015)
Semin Thromb Hemost. 42: 147–154, Impact factor: 3.629 (2017) - Point-of-Care Coagulation Monitoring in Trauma Patients.
Stein P, Kaserer A, Spahn G H, Spahn D R (2017)
Semin Thromb Hemost. 43: 367–374, Impact factor: 3.629 (2017) - „Patient blood management“ ist heute Standard.
Spahn D R, Kaserer A, Spahn G H, Stein P (2017)
Schweiz Med Forum. 17: 1145-1147, Impact factor: 2.068 (2017) - Patient Blood Management: Der Standard heute
Kaserer A, Stein P, Spahn G H, Spahn D R (2017)
Ther Umsch. 74: 369-376, Impact factor: 0.18 (2017)
- Repression of T-cell function by thionamides is mediated by inhibition of the activator protein-1/nuclear factor of activated T-cells pathway and is associated with a common structure.