Endokrinologie und
Diabetologie

Ärztliche Tätigkeit

seit 07/2017
Leitende Ärztin
Fachabteilung Endokrinologie und Diabetologie
Department Medizin
Kantonsspital Winterthur

07/2016 – 06/2017
Oberärztin
Fachabteilung Endokrinologie und Diabetologie
Department Medizin
Kantonsspital Winterthur

04/2014 – 05/2016 
Praxis Hormon Zentrum Zürich
Belegärztin Klinik Hirslanden

08/2010 – 03/2014 
Oberärztin
Fachbereich Endokrinologie, Diabetologie, Osteologie
Kantonsspital St. Gallen
(Fachsbereichleiter, Prof. Dr. med. M. Brändle)

02/2009 – 06/2010
Assistenzärztin
Klinik für Endokrinologie, Diabetologie und Klinische Ernährung
Universitätsspital Zürich
(Klinikleiter Prof. Dr. med. G.A. Spinas)

01/2007 – 12/2008 
Stipendium des schweizerischen Nationalfonds
Clinical Research Fellow
Garvan Institute of Medical Research Sydney, Australien
Pituitary Research Unit, Head of Departement Prof. Ken Ho
Diabetes & Obesity Research Group, Head of Departement Prof. L.V. Campbell

12/2005 – 11/2006 
Fachassistenzärztin
Fachbereich Endokrinologie/Diabetologie
Kantonsspital St.Gallen
(Fachbereichsleiter PD Dr. med. M. Brändle)

11/2004 – 11/2005  
Assistenzärztin
Departement Innere Medizin
Universitätsspital Zürich
(Chefarzt Prof. Dr. med. A. Schaffner/Prof. Dr. med. R. Follath)

06/2002 – 10/2004 
Assistenzärztin
Departement Innere Medizin
Kantonsspital St. Gallen
(Chefarzt Prof. Dr. med. R. L. Galeazzi/ Prof. Dr. med. P. Greminger)

06/2001 – 05/2002 
Assistenzärztin
Chirurgische Klinik
Spital Limmattal
(Chefarzt Prof. Dr. med. O. Schöb)

01 – 05/2001  
Gastärztin
Medizinische Klinik Nordland Sentralsykehus
Bodø, Norwegen
(Chefärztin Dr. med. M. Eskeland)

Ausbildung

11/2009
Fachärztin Endokrinologie/Diabetologie FMH

10/2006
Fachärztin Innere Medizin FMH

2002
Promotion zur Doktorin der Medizin

Dissertation:
“C-reactive protein and relative lymphocyte count as predictor of free wall rupture in patients with acute myocardial infarction”
(PD Dr. med. F. Salomon, Universitätsspital Zürich)

04 – 07/1996
China Beijing International Acupuncture Training Centre (WHO)
Grundausbildung in Akupunktur und Moxibustion

1993 – 2000
Studium der Humanmedizin, Universität Zürich

Postprandial metabolism in adults with Prader-Willi syndrome.
Purtell L, Viardot A, Sze L, Loughnan G, Steinbeck K, Sainsbury A, Herzog H, Smith A, Campbell LV.
Obesity (Silver Spring). 2015 Jun;23(6):1159-65.

Effect of Growth hormone replacement therapy on soluble Klotho in patients with Growth hormone deficiency.
Locher R, Egger A, Zwimpfer C, Sze L, Schmid C, Christ E.
Clin Endocrinol (Oxf). 2015 Feb 18.

Liraglutide as add-on therapy to insulin in type 2 diabetes mellitus: a retrospective, observational study from a daily clinical practice setting in Switzerland.
Lipowsky C, Sze L, Krull I, Brändle M.
Diabetes Ther. 2015 Mar;6(1):41-7.

Effects of age, sex, and estrogen on serum phosphorus: role for growth hormone and klotho?
Sze L, Schmid C.
Am J Kidney Dis. 2014 Jul;64(1):157-8.

Hypophyseninsuffizienz
Möller-Goede D, Sze L, Schmid C.
Schweiz Med Forum 2014,14 (49):927-931

Impact of Growth Hormone on Cystatin C.
Sze L, Bernays RL, Zwimpfer C, Wiesli P, Brändle M, Schmid C.
Nephron Extra. 2013 Nov 20;3(1):118-124.

Gender dependence of serum soluble Klotho in acromegaly.
Sze L, Neidert MC, Bernays RL, Zwimpfer C, Wiesli P, Haile S, Brändle M, Schmid C.
Clin Endocrinol (Oxf). 2014 Jun;80(6):869-73.

Growth hormone and α-Klotho,
Schmid C, Neidert MC, Tschopp O, Sze L, Bernays RL.
J Endocrinol. 2013 Nov 1;219(2):R37-57.

Monitoring for potential residual disease activity by serum insulin-like growth factor 1 and soluble Klotho in patients with acromegaly after pituitary surgery: Is there an impact of the genomic deletion of exon 3 in the growth hormone receptor (d3-GHR) gene on “safe” GH cut-off values?
Kohler S, Tschopp O, Sze L, Neidert M, Bernays RL, Spanaus KS, Wiesli P, Schmid C.
Gen Comp Endocrinol. 2013 Jul 1;188:282-7.

Postprandial cardiac autonomic function in Prader-Willi syndrome.
Purtell L, Jenkins A, Viardot A, Herzog H, Sainsbury A, Smith A, Loughnan G, Steinbeck K, Campbell LV, Sze L.
Clin Endocrinol (Oxf). 2013 Jul;79(1):128-33.

In adults with Prader-Willi syndrome, elevated ghrelin levels are more consistent with hyperphagia than high PYY and GLP-1 levels.
Purtell L, Sze L, Loughnan G, Smith E, Herzog H, Sainsbury A, Steinbeck K, Campbell LV, Viardot A.
Neuropeptides. 2011 Aug;45(4):301-7.

Effects of a single dose of exenatide on appetite, gut hormones, and glucose homeostasis in adults with prader-willi syndrome.
Sze L, Purtell L, Jenkins A, Loughnan G, Smith E, Herzog H, Sainsbury A, Steinbeck K, Campbell LV, Viardot A.
J Clin Endocrinol Metab. 2011 Aug;96(8):E1314-9.

Soluble α-klotho: a novel serum biomarker for the activity of GH-producing pituitary adenomas.
Neidert MC, Sze L, Zwimpfer C, Sarnthein J, Seifert B, Frei K, Leske H, Rushing EJ, Schmid C, Bernays RL.
Eur J Endocrinol. 2013 Mar 15;168(4):575-83.

Prader-Willi syndrome is associated with activation of the innate immune system independently of central adiposity and insulin resistance.
Viardot A, Sze L, Purtell L, Sainsbury A, Loughnan G, Smith E, Herzog H, Steinbeck K, Campbell LV.
J Clin Endocrinol Metab. 2010 Jul;95(7):3392-9.

Moderate amounts of fructose consumption impair insulin sensitivity in healthy young men: a randomized controlled trial.
Aeberli I, Hochuli M, Gerber PA, Sze L, Murer SB, Tappy L, Spinas GA, Berneis K.
Diabetes Care. 2013 Jan;36(1):150-6.

Excessively high soluble Klotho in patients with acromegaly.
Sze L, Bernays RL, Zwimpfer C, Wiesli P, Brändle M, Schmid C.
J Intern Med. 2012 Jul;272(1):93-7.
(Preis für beste oral Presentation Jahresversammlung SGED)

Effect of transsphenoidal surgery on sleep apnoea in acromegaly.
Sze L, Schmid C, Bloch KE, Bernays R, Brändle M.
Eur J Endocrinol. 2007 Mar;156(3):321-9.

A patient with a “good nose”.
Sze L, Fretz C, Hildebrandt G, Westphal K, Brändle M.
Exp Clin Endocrinol Diabetes. 2008 Feb;116(2):129-31.

Severe hypernatraemia due to nephrogenic diabetes insipidus – a life-threatening side effect of chronic lithium therapy.
Sze L, Ulrich B, Brändle M.
Exp Clin Endocrinol Diabetes. 2006 Nov;114(10):596-8.